Rab3b RAB3B, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab3bprovided by RGD
Official Full Name: RAB3B, member RAS oncogene familyprovided by RGD
Primary source: RGD:620922
See related: Ensembl:ENSRNOG00000008001 AllianceGenome:RGD:620922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GDP binding activity; GTP-dependent protein binding activity; and myosin V binding activity. Predicted to be involved in several processes, including positive regulation of dopamine uptake involved in synaptic transmission; regulation of vesicle-mediated transport; and secretion by cell. Predicted to act upstream of or within peptidyl-cysteine methylation. Located in cytosol. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB3B (RAB3B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 289.5), Brain (RPKM 80.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (128859034..128926087)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (123629562..123697410)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (128501789..128568170)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB3B improves dopamine handling and storage capacity at presynaptic terminals, and confers protection to vulnerable DA neurons.
Title: Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.
Rab3A, but not Rab3B, enhances secretory output from rat melanotrophs and that their function is not redundant.
Title: Distinct role of Rab3A and Rab3B in secretory activity of rat melanotrophs.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128978 (e-PCR)
- UniSTS:212286

RH136876 (e-PCR)
- UniSTS:218965

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	NAS Non-traceable Author Statement more info	PubMed
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin V binding	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dopamine uptake involved in synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dopamine uptake involved in synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of synaptic vesicle cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle size	IEA Inferred from Electronic Annotation more info
involved_in regulation of vesicle size	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dopaminergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031091.2 → NP_112353.1 ras-related protein Rab-3B

See identical proteins and their annotated locations for NP_112353.1

Status: VALIDATED

Source sequence(s)

BF524240, BI293875, CB711467, Y14019

UniProtKB/Swiss-Prot

Q63941

UniProtKB/TrEMBL

A6JYX0

Conserved Domains (2) summary

smart00175
Location:23 → 183

RAB; Rab subfamily of small GTPases

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

128859034..128926087

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238531.5 → XP_006238593.1 ras-related protein Rab-3B isoform X1

See identical proteins and their annotated locations for XP_006238593.1

UniProtKB/TrEMBL

Q6P9W6

Related

ENSRNOP00000010645.6

Conserved Domains (2) summary

smart00175
Location:23 → 192

RAB; Rab subfamily of small GTPases

cl21455
Location:22 → 195

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_063288471.1 → XP_063144541.1 ras-related protein Rab-3B isoform X1

UniProtKB/TrEMBL

Q6P9W6
XM_063288472.1 → XP_063144542.1 ras-related protein Rab-3B isoform X2

UniProtKB/Swiss-Prot

Q63941

UniProtKB/TrEMBL

A6JYX0