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SLCO5A1 solute carrier organic anion transporter family member 5A1 [ Homo sapiens (human) ]

Gene ID: 81796, updated on 10-Dec-2024

Summary

Official Symbol
SLCO5A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 5A1provided by HGNC
Primary source
HGNC:HGNC:19046
See related
Ensembl:ENSG00000137571 MIM:613543; AllianceGenome:HGNC:19046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATPJ; OATP-J; OATP5A1; OATPRP4; OATP-RP4; SLC21A15
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in small intestine (RPKM 68.6), ovary (RPKM 66.6) and 25 other tissues See more
Orthologs
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Genomic context

See SLCO5A1 in Genome Data Viewer
Location:
8q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (69667046..69834978, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (70096700..70264566, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (70579281..70747213, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1603 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:70378771-70379311 Neighboring gene sulfatase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr8:70451186-70451687 Neighboring gene MPRA-validated peak7064 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:70556317-70556868 Neighboring gene Sharpr-MPRA regulatory region 11728/13723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:70623385-70623885 Neighboring gene uncharacterized LOC105375889 Neighboring gene RN7SK pseudogene 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19263 Neighboring gene Sharpr-MPRA regulatory region 147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27501 Neighboring gene TMX1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19265 Neighboring gene SLCO5A1 antisense RNA 1 Neighboring gene BAG cochaperone 4 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 675, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39560

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
solute carrier organic anion transporter family member 5A1
Names
organic anion transporter polypeptide-related protein 4
solute carrier family 21 (organic anion transporter), member 15
solute carrier family 21 member 15

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146008.2NP_001139480.1  solute carrier organic anion transporter family member 5A1 isoform 2

    See identical proteins and their annotated locations for NP_001139480.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079089, AC091047, AF205075, AK022760, CA449383
    Consensus CDS
    CCDS55243.1
    UniProtKB/Swiss-Prot
    Q9H2Y9
    Related
    ENSP00000434422.1, ENST00000524945.5
    Conserved Domains (3) summary
    cd06174
    Location:131531
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:551605
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129674
    OATP; Organic Anion Transporter Polypeptide (OATP) family
  2. NM_001146009.1NP_001139481.1  solute carrier organic anion transporter family member 5A1 isoform 3

    See identical proteins and their annotated locations for NP_001139481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC079089, AC091047, AF205075, BC139755, CA449383
    Consensus CDS
    CCDS55242.1
    UniProtKB/Swiss-Prot
    Q9H2Y9
    Related
    ENSP00000431611.1, ENST00000530307.1
    Conserved Domains (1) summary
    cd17404
    Location:128620
    MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters
  3. NM_030958.3NP_112220.2  solute carrier organic anion transporter family member 5A1 isoform 1

    See identical proteins and their annotated locations for NP_112220.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC091047, AK096879, BC137424, CA449383
    Consensus CDS
    CCDS6205.1
    UniProtKB/Swiss-Prot
    A4QPC2, B2RPF7, B3KMU7, E9PKK5, G3V1C0, Q9H2Y9
    Related
    ENSP00000260126.3, ENST00000260126.9
    Conserved Domains (3) summary
    cd06174
    Location:131531
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:551605
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129734
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    69667046..69834978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    70096700..70264566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)