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Tgfbr2 transforming growth factor, beta receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81810, updated on 4-Jan-2025

Summary

Official Symbol
Tgfbr2provided by RGD
Official Full Name
transforming growth factor, beta receptor 2provided by RGD
Primary source
RGD:69651
See related
EnsemblRapid:ENSRNOG00000013265 AllianceGenome:RGD:69651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tgfbr2T; TGF-beta 2
Summary
Enables mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including cellular response to acetaldehyde; negative regulation of cardiac muscle cell proliferation; and transforming growth factor beta receptor signaling pathway. Located in caveola and cell surface. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 782.6), Adrenal (RPKM 511.9) and 8 other tissues See more
Orthologs
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Genomic context

See Tgfbr2 in Genome Data Viewer
Location:
8q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (124672677..124761741, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (115794537..115883615, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (124310288..124399345, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094283 Neighboring gene glutamate decarboxylase-like 1 Neighboring gene uncharacterized LOC120094284 Neighboring gene uncharacterized LOC103690469

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 35
Function Evidence Code Pubs
enables ATP binding  
enables BMP receptor activity  
enables SMAD binding  
enables SMAD binding  
enables activin binding  
enables activin receptor activity, type I  
enables activin receptor activity, type I  
enables activin receptor activity, type II  
enables glycosaminoglycan binding  
enables glycosaminoglycan binding  
enables kinase activator activity  
enables kinase activator activity  
enables metal ion binding  
enables mitogen-activated protein kinase kinase kinase binding PubMed 
enables molecular adaptor activity  
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
enables protein-containing complex binding PubMed 
enables transforming growth factor beta binding  
enables transforming growth factor beta binding  
contributes_to transforming growth factor beta binding  
enables transforming growth factor beta binding  
enables transforming growth factor beta receptor activity  
enables transforming growth factor beta receptor activity  
enables transforming growth factor beta receptor activity, type I  
enables transforming growth factor beta receptor activity, type II  
enables transforming growth factor beta receptor activity, type II PubMed 
enables transforming growth factor beta receptor activity, type II  
enables transforming growth factor beta receptor activity, type II PubMed 
enables transforming growth factor beta receptor activity, type III  
enables transmembrane receptor protein serine/threonine kinase activity  
enables type I transforming growth factor beta receptor binding  
enables type I transforming growth factor beta receptor binding  
enables type I transforming growth factor beta receptor binding  
enables type III transforming growth factor beta receptor binding  
Items 1 - 25 of 35
Items 1 - 25 of 141
Process Evidence Code Pubs
involved_in BMP signaling pathway  
involved_in Langerhans cell differentiation  
acts_upstream_of_or_within Langerhans cell differentiation  
involved_in Notch signaling pathway  
acts_upstream_of_or_within Notch signaling pathway  
involved_in SMAD protein signal transduction  
acts_upstream_of_or_within SMAD protein signal transduction  
involved_in activin receptor signaling pathway  
involved_in activin receptor signaling pathway  
involved_in animal organ morphogenesis PubMed 
involved_in animal organ regeneration PubMed 
involved_in aorta morphogenesis  
involved_in aorta morphogenesis  
involved_in aortic valve morphogenesis  
involved_in aortic valve morphogenesis  
involved_in apoptotic process  
involved_in artery morphogenesis  
involved_in atrioventricular valve morphogenesis  
involved_in brain development  
involved_in brain development  
involved_in branching involved in blood vessel morphogenesis  
acts_upstream_of_or_within branching involved in blood vessel morphogenesis  
acts_upstream_of_or_within bronchus development  
involved_in bronchus morphogenesis  
acts_upstream_of_or_within bronchus morphogenesis  
involved_in cardiac left ventricle morphogenesis  
involved_in cardiac left ventricle morphogenesis  
involved_in cartilage development  
NOT involved_in cell proliferation involved in endocardial cushion morphogenesis  
involved_in cellular response to acetaldehyde PubMed 
involved_in cellular response to growth factor stimulus  
involved_in digestive tract development PubMed 
involved_in embryo implantation PubMed 
involved_in embryonic cranial skeleton morphogenesis  
involved_in embryonic cranial skeleton morphogenesis  
involved_in embryonic hemopoiesis  
involved_in embryonic hemopoiesis  
involved_in endocardial cushion fusion  
involved_in endocardial cushion fusion  
involved_in epithelial to mesenchymal transition  
involved_in epithelial to mesenchymal transition  
involved_in gastrulation  
acts_upstream_of_or_within gastrulation  
involved_in growth plate cartilage chondrocyte growth  
acts_upstream_of_or_within growth plate cartilage chondrocyte growth  
acts_upstream_of_or_within growth plate cartilage development  
involved_in heart development  
acts_upstream_of_or_within heart development  
involved_in heart looping  
involved_in heart looping  
involved_in in utero embryonic development  
acts_upstream_of_or_within in utero embryonic development  
involved_in inferior endocardial cushion morphogenesis  
involved_in inferior endocardial cushion morphogenesis  
involved_in lens development in camera-type eye  
acts_upstream_of_or_within lens development in camera-type eye  
involved_in lens fiber cell apoptotic process  
acts_upstream_of_or_within lens fiber cell apoptotic process  
involved_in lung development PubMed 
acts_upstream_of_or_within lung development  
involved_in lung lobe morphogenesis  
acts_upstream_of_or_within lung lobe morphogenesis  
acts_upstream_of_or_within lung morphogenesis  
involved_in mammary gland morphogenesis  
acts_upstream_of_or_within mammary gland morphogenesis  
involved_in membranous septum morphogenesis  
involved_in membranous septum morphogenesis  
involved_in miRNA transport  
involved_in miRNA transport  
involved_in negative regulation of cardiac muscle cell proliferation PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in nervous system development  
involved_in outflow tract morphogenesis  
involved_in outflow tract septum morphogenesis  
involved_in outflow tract septum morphogenesis  
involved_in positive regulation of B cell tolerance induction  
acts_upstream_of_or_within positive regulation of B cell tolerance induction  
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation  
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation  
involved_in positive regulation of NK T cell differentiation  
acts_upstream_of_or_within positive regulation of NK T cell differentiation  
involved_in positive regulation of SMAD protein signal transduction  
involved_in positive regulation of SMAD protein signal transduction  
involved_in positive regulation of T cell tolerance induction  
acts_upstream_of_or_within positive regulation of T cell tolerance induction  
involved_in positive regulation of angiogenesis  
acts_upstream_of_or_within positive regulation of angiogenesis  
involved_in positive regulation of epithelial cell migration  
acts_upstream_of_or_within positive regulation of epithelial cell migration  
involved_in positive regulation of epithelial to mesenchymal transition  
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
involved_in positive regulation of mesenchymal cell proliferation  
involved_in positive regulation of mesenchymal cell proliferation  
involved_in positive regulation of reactive oxygen species metabolic process  
involved_in positive regulation of reactive oxygen species metabolic process  
involved_in positive regulation of skeletal muscle tissue regeneration PubMed 
involved_in positive regulation of smooth muscle cell proliferation PubMed 
involved_in positive regulation of tolerance induction to self antigen  
acts_upstream_of_or_within positive regulation of tolerance induction to self antigen  
involved_in receptor-mediated endocytosis PubMed 
acts_upstream_of_or_within regulation of cell population proliferation  
involved_in regulation of gene expression  
acts_upstream_of_or_within regulation of gene expression  
involved_in regulation of stem cell differentiation  
involved_in regulation of stem cell differentiation  
involved_in regulation of stem cell proliferation  
acts_upstream_of_or_within regulation of stem cell proliferation  
involved_in response to cholesterol  
involved_in response to cholesterol  
involved_in response to estrogen PubMed 
involved_in response to glucose PubMed 
involved_in response to hypoxia PubMed 
involved_in response to hypoxia PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to nutrient PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to steroid hormone PubMed 
involved_in response to xenobiotic stimulus  
involved_in response to xenobiotic stimulus  
involved_in roof of mouth development  
involved_in secondary palate development  
involved_in secondary palate development  
involved_in smoothened signaling pathway  
acts_upstream_of_or_within smoothened signaling pathway  
NOT involved_in superior endocardial cushion morphogenesis  
involved_in trachea formation  
acts_upstream_of_or_within trachea formation  
acts_upstream_of_or_within trachea morphogenesis  
involved_in transforming growth factor beta receptor signaling pathway  
involved_in transforming growth factor beta receptor signaling pathway PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway  
involved_in transforming growth factor beta receptor signaling pathway  
involved_in transforming growth factor beta receptor signaling pathway PubMed 
involved_in tricuspid valve morphogenesis  
involved_in tricuspid valve morphogenesis  
involved_in vasculogenesis  
involved_in vasculogenesis PubMed 
involved_in vasculogenesis  
involved_in ventricular septum morphogenesis  
Items 1 - 25 of 141
Component Evidence Code Pubs
part_of activin receptor complex  
located_in caveola PubMed 
located_in caveola  
located_in caveola  
located_in cell surface PubMed 
located_in external side of plasma membrane  
located_in external side of plasma membrane  
located_in extracellular space  
located_in membrane  
located_in membrane raft PubMed 
located_in membrane raft  
is_active_in plasma membrane  
located_in plasma membrane  
part_of receptor complex  
part_of transforming growth factor beta ligand-receptor complex  
part_of transforming growth factor beta ligand-receptor complex  

General protein information

Preferred Names
TGF-beta receptor type-2
Names
TGF-beta receptor type II
TGF-beta type II receptor
TGFR-2
tbetaR-II
transforming growth factor beta receptor type II
transforming growth factor, beta receptor II
transforming growth factor, beta receptor IIT
transforming growth factor-b type II receptor
transforming growth factor-beta type II receptor
NP_112394.4
XP_008764912.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031132.4 → NP_112394.4  TGF-beta receptor type-2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P38438
    UniProtKB/TrEMBL
    D0VED2
    Related
    ENSRNOP00000093892.1, ENSRNOT00000116107.2
    Conserved Domains (2) summary
    cd14055
    Location:248 → 542
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:49 → 152
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    124672677..124761741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766690.2 → XP_008764912.1  TGF-beta receptor type-2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QK15
    Related
    ENSRNOP00000035501.4, ENSRNOT00000037883.6
    Conserved Domains (3) summary
    smart00221
    Location:269 → 566
    STYKc; Protein kinase; unclassified specificity
    cd14055
    Location:273 → 567
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:74 → 177
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain
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