Siglece sialic acid binding Ig-like lectin E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sigleceprovided by MGI
Official Full Name: sialic acid binding Ig-like lectin Eprovided by MGI
Primary source: MGI:MGI:1932475
See related: Ensembl:ENSMUSG00000030474 AllianceGenome:MGI:1932475
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd170; Siglec5; Siglec9; Siglec12; Siglecl1; mSiglec-E
Summary: Enables monosaccharide binding activity and sialic acid binding activity. Acts upstream of or within cell adhesion; negative regulation of inflammatory response; and negative regulation of phagocytosis, engulfment. Located in external side of plasma membrane. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including SIGLEC8 (sialic acid binding Ig like lectin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 9.7), liver E18 (RPKM 3.5) and 19 other tissues See more
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43300494..43309585, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43648882..43672044, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
Title: The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
The prognostic impact of SIGLEC5-induced impairment of CD8[+] T cell activation in sepsis.
Title: The prognostic impact of SIGLEC5-induced impairment of CD8(+) T cell activation in sepsis.
O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells.
Title: O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells.
Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.
Title: Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.
Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.
Title: Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.
Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-kappaB pathway.
Title: Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.
The Siglec-E-deficient dendritic cells were defective for TRIF-mediated IFN-beta production in response to E. coli infection.
Title: Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis.
This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1.
Title: Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.
new data relating to the structure and function of Siglec-E, the major CD33-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.
Title: Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.
indicate that Siglec-9 affects several different signaling pathways in IL-4-stimulated macrophages, which resulted in enhanced induction of Arg1 in Siglec-9-expressing RAW264 cells
Title: Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sialic acid-binding Ig-like lectin 12

Names: MIS; SIGLEC-like 1; myeloid inhibitory siglec; sialic acid binding Ig-like lectin 5; sialic acid-binding Ig-like lectin-like 1; sialic acid-binding immunoglobulin-like lectin E; siglec-12; siglec-5; siglec-E; siglec-L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031181.2 → NP_112458.2 sialic acid-binding Ig-like lectin 12 precursor

See identical proteins and their annotated locations for NP_112458.2

Status: VALIDATED

Source sequence(s)

AC151989

Consensus CDS

CCDS21178.1

UniProtKB/Swiss-Prot

E9QMD1, Q91Y57

UniProtKB/TrEMBL

Q6PJ50

Related

ENSMUSP00000032667.9, ENSMUST00000032667.10

Conserved Domains (3) summary

smart00408
Location:270 → 330

IGc2; Immunoglobulin C-2 Type

smart00410
Location:264 → 339

IG_like; Immunoglobulin like

cl11960
Location:25 → 146

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43300494..43309585 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541320.5 → XP_006541383.1 sialic acid-binding Ig-like lectin 12 isoform X3

Conserved Domains (2) summary

pfam13927
Location:171 → 233

Ig_3; Immunoglobulin domain

cl11960
Location:25 → 146

Ig; Immunoglobulin domain
XM_006541321.5 → XP_006541384.1 sialic acid-binding Ig-like lectin 12 isoform X4

Conserved Domains (2) summary

pfam13927
Location:264 → 326

Ig_3; Immunoglobulin domain

cl11960
Location:25 → 146

Ig; Immunoglobulin domain
XM_006541318.5 → XP_006541381.1 sialic acid-binding Ig-like lectin 12 isoform X1

UniProtKB/TrEMBL

Q6PJ50

Conserved Domains (2) summary

pfam13927
Location:264 → 326

Ig_3; Immunoglobulin domain

cl11960
Location:25 → 146

Ig; Immunoglobulin domain
XM_006541319.5 → XP_006541382.1 sialic acid-binding Ig-like lectin 12 isoform X2

UniProtKB/TrEMBL

Q6PJ50

Conserved Domains (2) summary

pfam13927
Location:264 → 326

Ig_3; Immunoglobulin domain

cl11960
Location:25 → 146

Ig; Immunoglobulin domain