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Parg poly (ADP-ribose) glycohydrolase [ Rattus norvegicus (Norway rat) ]

Gene ID: 83507, updated on 30-Mar-2024

Summary

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Official Symbol
Pargprovided by RGD
Official Full Name
poly (ADP-ribose) glycohydrolaseprovided by RGD
Primary source
RGD:620387
See related
Ensembl:ENSRNOG00000019978 AllianceGenome:RGD:620387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables chromatin binding activity and poly(ADP-ribose) glycohydrolase activity. Involved in positive regulation of DNA repair. Located in chromatin and nucleus. Used to study brain infarction. Biomarker of borna disease. Orthologous to several human genes including BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 282.5), Adrenal (RPKM 216.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p16
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (7442696..7550585)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (7436429..7544276)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (8350168..8457999)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase like 1 Neighboring gene nuclear receptor coactivator 4 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene uncharacterized LOC134482454 Neighboring gene uncharacterized LOC102550503 Neighboring gene oxoglutarate dehydrogenase L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element. Kim IK, et al. Nat Struct Mol Biol, 2012 May 20. PMID 22609859, Free PMC Article
  2. Active poly(ADPribose) metabolism in DNAase- and salt-resistant rat testis chromatin with high transcriptional activity/competence. Mennella MR, et al. J Cell Biochem, 2003 Jul 1. PMID 12858335
  3. Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat. Lu XC, et al. Brain Res, 2003 Jul 18. PMID 12834903
  4. Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: presence of a potential nuclear export signal conserved in mammalian orthologs. Shimokawa T, et al. J Biochem, 1999 Oct. PMID 10502684
  5. Poly(ADPribosyl)ation system in rat germinal cells at different stages of differentiation. Quesada P, et al. Exp Cell Res, 1996 Jul 10. PMID 8660954

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study reports the crystal structures of Parg and its complex with a substrate mimic that reveal an open substrate-binding site and a unique 'tyrosine clasp' enabling endoglycosidic cleavage of branched PAR chains.
    Title: Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
  2. PARG is expressed in the nuclear fraction of primary spermatocytes and in the post-nuclear fraction of round spermatids
    Title: Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells.
  3. poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase have key roles in germinal cells as key proteins in processes that sense and repair DNA damage as well as in the commitment to apoptosis following prolonged oxidative stress
    Title: Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors.
  4. results suggest that poly (ADP-ribose) glycohydrolase(PARG) activity modulates the inflammatory response in ischemia/reperfusion and participates in end (target) organ damage under these conditions
    Title: PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(ADP-ribose) glycohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(ADP-ribose) glycohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(ADP-ribose) glycohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(ADP-ribose) glycohydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP generation from poly-ADP-D-ribose IEA
Inferred from Electronic Annotation
more info
  
involved_in ATP generation from poly-ADP-D-ribose ISO
Inferred from Sequence Orthology
more info
  
involved_in ATP generation from poly-ADP-D-ribose ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detection of bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-sugar metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly(ADP-ribose) glycohydrolase
NP_112629.2
XP_006252731.1
XP_017455747.1
XP_038950789.1
XP_038950791.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031339.2 → NP_112629.2  poly(ADP-ribose) glycohydrolase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q9QYM2
    UniProtKB/TrEMBL
    A6KFW3, G3V8M8
    Related
    ENSRNOP00000027071.4, ENSRNOT00000027071.5
    Conserved Domains (2) summary
    pfam05028
    Location:577 → 902
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    NF033609
    Location:181 → 398
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    7442696..7550585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600258.3 → XP_017455747.1  poly(ADP-ribose) glycohydrolase isoform X2

    UniProtKB/Swiss-Prot
    Q9QYM2
    UniProtKB/TrEMBL
    A6KFW4
    Conserved Domains (2) summary
    pfam01439
    Location:145 → 162
    Metallothio_2; Metallothionein
    pfam05028
    Location:494 → 822
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  2. XM_039094861.2 → XP_038950789.1  poly(ADP-ribose) glycohydrolase isoform X1

    UniProtKB/Swiss-Prot
    Q9QYM2
    Conserved Domains (2) summary
    pfam05028
    Location:569 → 871
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    NF033609
    Location:181 → 398
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  3. XM_039094863.2 → XP_038950791.1  poly(ADP-ribose) glycohydrolase isoform X4

    Conserved Domains (1) summary
    NF033609
    Location:181 → 398
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

  4. XM_006252669.3 → XP_006252731.1  poly(ADP-ribose) glycohydrolase isoform X3

    UniProtKB/Swiss-Prot
    Q9QYM2
    Conserved Domains (2) summary
    pfam01439
    Location:122 → 139
    Metallothio_2; Metallothionein
    pfam05028
    Location:471 → 799
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

RNA

  1. XR_005494674.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYM2.1 GenPept UniProtKB/Swiss-Prot:Q9QYM2

Gene LinkOut

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