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Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 83521, updated on 5-Mar-2024

Summary

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Official Symbol
Rradprovided by RGD
Official Full Name
RRAD, Ras related glycolysis inhibitor and calcium channel regulatorprovided by RGD
Primary source
RGD:69357
See related
Ensembl:ENSRNOG00000011901 AllianceGenome:RGD:69357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity and calcium channel regulator activity. Involved in negative regulation of cell growth. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 894.3), Muscle (RPKM 95.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
19p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (360581..363874)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (354184..357424)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (561696..564929)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 29, pseudogene 1 Neighboring gene cytosolic iron-sulfur assembly component 2B Neighboring gene cadherin 16 Neighboring gene uncharacterized LOC120098574 Neighboring gene pyruvate dehydrogenase phosphatase catalytic subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ras associated with diabetes may play a role in fracture nonunion development in rats. Oda T, et al. BMC Musculoskelet Disord, 2019 Dec 12. PMID 31830958, Free PMC Article
  2. Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart. Wang G, et al. Circ Res, 2010 Feb 5. PMID 19926875
  3. A novel Rad gene polymorphism combined with obesity increases risk for type 2 diabetes mellitus. Wang GY, et al. Chin Med J (Engl), 2004 May. PMID 15161552
  4. Analysis of trinucleotide-repeat combination polymorphism at the rad gene in patients with type 2 diabetes mellitus. Yuan X, et al. Metabolism, 1999 Feb. PMID 10024077
  5. Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase. Sun Z, et al. Biochem Biophys Res Commun, 2011 May 27. PMID 21549102

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28
    Title: Ras associated with diabetes may play a role in fracture nonunion development in rats.
  2. Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs
    Title: Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
  3. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor in failing hearts.
    Title: Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor.
  4. Rad-triggered apoptosis was mediated by the activation of p38 MAPK.
    Title: Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.
  5. Results establish Rad as a novel endogenous regulator of cardiac EC coupling and betaAR signaling and support a parsimonious model in which Rad buffers Ca(v)beta to modulate LCC activity, EC coupling, and betaAR responsiveness.
    Title: Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.
  6. Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway
    Title: Rad GTPase deficiency leads to cardiac hypertrophy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP-binding protein RAD
Names
RAD1
Ras-related associated with diabetes
ras associated with diabetes
NP_445790.2
XP_006255117.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053338.2 → NP_445790.2  GTP-binding protein RAD

    See identical proteins and their annotated locations for NP_445790.2

    Status: VALIDATED

    Source sequence(s)
    CK602305, CK840773, FM054321, FM055705
    UniProtKB/Swiss-Prot
    P55043
    UniProtKB/TrEMBL
    A6JXU5, G3V7K9
    Conserved Domains (2) summary
    cd04148
    Location:91 → 307
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:91 → 251
    RAS; Ras subfamily of RAS small GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    360581..363874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255055.5 → XP_006255117.1  GTP-binding protein RAD isoform X1

    See identical proteins and their annotated locations for XP_006255117.1

    UniProtKB/Swiss-Prot
    P55043
    UniProtKB/TrEMBL
    A6JXU5, G3V7K9
    Related
    ENSRNOP00000016259.2
    Conserved Domains (2) summary
    cd04148
    Location:91 → 307
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
    smart00173
    Location:91 → 251
    RAS; Ras subfamily of RAS small GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55043.2 GenPept UniProtKB/Swiss-Prot:P55043

Gene LinkOut

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