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Nefl neurofilament light chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 83613, updated on 4-Jan-2025

Summary

Official Symbol
Neflprovided by RGD
Official Full Name
neurofilament light chainprovided by RGD
Primary source
RGD:621458
See related
EnsemblRapid:ENSRNOG00000013658 AllianceGenome:RGD:621458
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nfl; NF-L; NF68
Summary
Enables phospholipase binding activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; intermediate filament cytoskeleton organization; and response to corticosterone. Located in growth cone and neurofilament. Used to study congenital hypothyroidism. Biomarker of depressive disorder; hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light chain). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 1441.6) See more
Orthologs
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Genomic context

See Nefl in Genome Data Viewer
Location:
15p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (46477330..46481203)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (42301920..42305793)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (44799378..44803251)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 5 Neighboring gene ribosomal protein S16, pseudogene 5 Neighboring gene solute carrier family 25 member 3, pseudogene 1 Neighboring gene cilia- and flagella-associated protein 251-like Neighboring gene neurofilament medium chain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 34
Process Evidence Code Pubs
involved_in anterograde axonal transport  
involved_in axonal transport of mitochondrion  
acts_upstream_of axonogenesis  
involved_in cerebral cortex development PubMed 
involved_in hippocampus development PubMed 
acts_upstream_of_or_within intermediate filament bundle assembly  
involved_in intermediate filament bundle assembly  
acts_upstream_of_or_within intermediate filament organization  
involved_in intermediate filament organization  
involved_in intermediate filament polymerization or depolymerization PubMed 
acts_upstream_of_or_within locomotion  
acts_upstream_of_or_within microtubule cytoskeleton organization  
acts_upstream_of motor neuron apoptotic process  
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process  
involved_in neurofilament bundle assembly  
involved_in neurofilament bundle assembly PubMed 
involved_in neurofilament bundle assembly  
acts_upstream_of_or_within neurofilament cytoskeleton organization  
acts_upstream_of_or_within neuromuscular process controlling balance  
acts_upstream_of_or_within neuron projection morphogenesis  
acts_upstream_of_or_within peripheral nervous system axon regeneration  
acts_upstream_of_or_within positive regulation of axonogenesis  
involved_in postsynaptic intermediate filament cytoskeleton organization  
involved_in postsynaptic modulation of chemical synaptic transmission  
involved_in protein polymerization PubMed 
acts_upstream_of_or_within regulation of axon diameter  
involved_in regulation of synapse maturation  
involved_in response to acrylamide PubMed 
involved_in response to corticosterone PubMed 
involved_in response to peptide hormone PubMed 
involved_in response to sodium arsenite PubMed 
involved_in response to toxic substance PubMed 
involved_in retrograde axonal transport  
involved_in spinal cord development PubMed 
Items 1 - 25 of 34
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse  
is_active_in axon  
located_in axon PubMed 
located_in axon  
located_in axon cytoplasm  
is_active_in cholinergic synapse  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in growth cone PubMed 
is_active_in intermediate filament  
located_in intermediate filament  
located_in neurofilament PubMed 
located_in neurofilament  
is_active_in neuromuscular junction  
located_in neuron projection  
is_active_in postsynaptic intermediate filament cytoskeleton  
is_active_in postsynaptic intermediate filament cytoskeleton  
is_active_in presynaptic intermediate filament cytoskeleton  

General protein information

Preferred Names
neurofilament light polypeptide
Names
68 kDa neurofilament protein
68kDa neurofilament
neurofilament triplet L protein
neurofilament, light polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031783.2NP_113971.1  neurofilament light polypeptide

    See identical proteins and their annotated locations for NP_113971.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P19527, Q63367
    UniProtKB/TrEMBL
    A6K6Q9
    Related
    ENSRNOP00000018599.2, ENSRNOT00000018599.5
    Conserved Domains (4) summary
    pfam00038
    Location:89400
    Filament; Intermediate filament protein
    pfam04732
    Location:988
    Filament_head; Intermediate filament head (DNA binding) region
    cd16269
    Location:212222
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:140239
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    46477330..46481203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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