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Rest RE1-silencing transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 83618, updated on 4-Jan-2025

Summary

Official Symbol
Restprovided by RGD
Official Full Name
RE1-silencing transcription factorprovided by RGD
Primary source
RGD:621069
See related
EnsemblRapid:ENSRNOG00000002074 AllianceGenome:RGD:621069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nrsf
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of biosynthetic process; negative regulation of dense core granule biogenesis; and response to ischemia. Located in chromatin and nucleus. Part of transcription repressor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 183.2), Spleen (RPKM 160.0) and 9 other tissues See more
Orthologs
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Genomic context

See Rest in Genome Data Viewer
Location:
14p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31213415..31233451, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (30859109..30879828, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (33131985..33152019, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 7 Neighboring gene RNA polymerase II subunit B Neighboring gene nitric oxide associated 1 Neighboring gene uncharacterized LOC102551532 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 29
Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA binding  
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity  
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II core promoter sequence-specific DNA binding  
enables RNA polymerase II-specific DNA-binding transcription factor binding  
enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding  
enables chromatin binding  
enables chromatin binding  
enables identical protein binding  
enables identical protein binding  
enables metal ion binding  
enables protein binding PubMed 
enables protein-containing complex binding PubMed 
enables sequence-specific DNA binding PubMed 
enables sequence-specific DNA binding  
enables sequence-specific DNA binding  
enables transcription cis-regulatory region binding  
enables transcription cis-regulatory region binding  
enables transcription cis-regulatory region binding  
Items 1 - 25 of 29
Items 1 - 25 of 99
Process Evidence Code Pubs
involved_in auditory receptor cell stereocilium organization  
involved_in auditory receptor cell stereocilium organization  
involved_in cardiac muscle cell myoblast differentiation  
involved_in cardiac muscle cell myoblast differentiation  
involved_in cellular response to electrical stimulus  
involved_in cellular response to electrical stimulus  
involved_in cellular response to electrical stimulus  
involved_in cellular response to glucocorticoid stimulus  
involved_in cellular response to glucocorticoid stimulus  
involved_in cellular response to glucocorticoid stimulus  
acts_upstream_of_or_within cellular response to stress  
involved_in cellular response to xenobiotic stimulus  
involved_in cellular response to xenobiotic stimulus  
involved_in cellular response to xenobiotic stimulus  
involved_in chromatin remodeling PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of sound  
involved_in detection of mechanical stimulus involved in sensory perception of sound  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation  
involved_in modification of synaptic structure PubMed 
involved_in negative regulation by host of viral transcription  
involved_in negative regulation by host of viral transcription  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of DNA-templated transcription PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of aldosterone biosynthetic process  
involved_in negative regulation of aldosterone biosynthetic process PubMed 
involved_in negative regulation of aldosterone biosynthetic process  
involved_in negative regulation of amniotic stem cell differentiation  
involved_in negative regulation of amniotic stem cell differentiation  
involved_in negative regulation of amniotic stem cell differentiation  
involved_in negative regulation of calcium ion-dependent exocytosis PubMed 
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of cell population proliferation  
involved_in negative regulation of cortisol biosynthetic process  
involved_in negative regulation of cortisol biosynthetic process PubMed 
involved_in negative regulation of cortisol biosynthetic process  
involved_in negative regulation of dense core granule biogenesis PubMed 
involved_in negative regulation of gene expression  
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of gene expression  
involved_in negative regulation of gene expression  
involved_in negative regulation of insulin secretion  
involved_in negative regulation of insulin secretion  
involved_in negative regulation of insulin secretion  
involved_in negative regulation of mesenchymal stem cell differentiation  
involved_in negative regulation of miRNA transcription  
involved_in negative regulation of miRNA transcription  
acts_upstream_of_or_within negative regulation of neurogenesis  
involved_in negative regulation of neurogenesis  
involved_in negative regulation of neuron differentiation  
involved_in negative regulation of neuron differentiation  
involved_in negative regulation of neuron differentiation PubMed 
involved_in negative regulation of neuron differentiation  
involved_in negative regulation of neuron differentiation  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II PubMed 
involved_in nervous system process  
involved_in nervous system process  
involved_in nervous system process  
involved_in neuromuscular process controlling balance  
involved_in neuromuscular process controlling balance  
involved_in neuron differentiation PubMed 
involved_in neuronal stem cell population maintenance  
involved_in neuronal stem cell population maintenance  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of cysteine-type endopeptidase activity  
involved_in positive regulation of cysteine-type endopeptidase activity  
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of neuron differentiation  
involved_in positive regulation of neuron differentiation  
involved_in positive regulation of programmed cell death PubMed 
involved_in positive regulation of stem cell population maintenance  
involved_in positive regulation of stem cell population maintenance  
involved_in positive regulation of stem cell population maintenance  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of DNA-templated transcription  
involved_in regulation of DNA-templated transcription  
involved_in regulation of alternative mRNA splicing, via spliceosome  
involved_in regulation of alternative mRNA splicing, via spliceosome  
acts_upstream_of_or_within regulation of gene expression  
involved_in regulation of osteoblast differentiation  
involved_in regulation of osteoblast differentiation  
involved_in response to hypoxia  
involved_in response to hypoxia  
involved_in response to hypoxia  
involved_in response to ischemia PubMed 
involved_in response to ischemia PubMed 
involved_in somatic stem cell population maintenance  
involved_in somatic stem cell population maintenance  
Items 1 - 25 of 99
Component Evidence Code Pubs
located_in chromatin PubMed 
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
located_in nucleus  
located_in nucleus  
part_of protein-containing complex PubMed 
part_of transcription repressor complex  
part_of transcription repressor complex PubMed 
part_of transcription repressor complex  
part_of transcription repressor complex  

General protein information

Preferred Names
RE1-silencing transcription factor
Names
neural-restrictive silencer factor
zinc finger transcription factor REST protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031788.2NP_113976.2  RE1-silencing transcription factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    F1M9A3
    Related
    ENSRNOP00000002837.6, ENSRNOT00000002837.8
    Conserved Domains (4) summary
    COG5048
    Location:270413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:317342
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:303327
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    31213415..31233451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250849.5XP_006250911.1  RE1-silencing transcription factor isoform X1

    See identical proteins and their annotated locations for XP_006250911.1

    UniProtKB/TrEMBL
    F1M9A3
    Conserved Domains (4) summary
    COG5048
    Location:270413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:317342
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:303327
    zf-H2C2_5; C2H2-type zinc-finger domain
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