U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gtf2a1 general transcription factor 2A subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83830, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gtf2a1provided by RGD
Official Full Name
general transcription factor 2A subunit 1provided by RGD
Primary source
RGD:69246
See related
Ensembl:ENSRNOG00000004300 AllianceGenome:RGD:69246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tf2a; TfIIa
Summary
Predicted to enable several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II general transcription initiation factor activity; and TBP-class protein binding activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIIA complex; transcription factor TFIID complex; and transcription preinitiation complex. Orthologous to human GTF2A1 (general transcription factor IIA subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 145.9), Kidney (RPKM 140.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (116219614..116252220, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (110488891..110521502, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (115321110..115352659, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 128 Neighboring gene thyroid stimulating hormone receptor Neighboring gene small nucleolar RNA SNORA79 Neighboring gene uncharacterized LOC134479244 Neighboring gene stonin 2 Neighboring gene acid phosphatase 1, pseudogene 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. Ma D, et al. Genes Dev, 1993 Nov. PMID 8224850
  2. Transcription factor IIA mutations show activator-specific defects and reveal a IIA function distinct from stimulation of TBP-DNA binding. Ozer J, et al. J Biol Chem, 1996 May 10. PMID 8626665
  3. Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. Sun X, et al. Genes Dev, 1994 Oct 1. PMID 7958900
  4. Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. DeJong J, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7724559, Free PMC Article
  5. Structural insights into transcription initiation by RNA polymerase II. Grünberg S, et al. Trends Biochem Sci, 2013 Dec. PMID 24120742, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIA complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIA complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription initiation factor IIA subunit 1
Names
TFIIA large subunit
general transcription factor 2a, 1
general transcription factor IIA subunit 1
general transcription factor IIa, 1 (37kD and 19kD subunits)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022208.2 → NP_071544.1  transcription initiation factor IIA subunit 1

    See identical proteins and their annotated locations for NP_071544.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    O08949
    UniProtKB/TrEMBL
    A0A8I6A0U6, A6JEC8
    Related
    ENSRNOP00000005873.1, ENSRNOT00000005873.4
    Conserved Domains (1) summary
    pfam03153
    Location:13 → 377
    TFIIA; Transcription factor IIA, alpha/beta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    116219614..116252220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240410.4 → XP_006240472.1  transcription initiation factor IIA subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APY1
    Conserved Domains (1) summary
    pfam03153
    Location:1 → 338
    TFIIA; Transcription factor IIA, alpha/beta subunit

  2. XM_039112999.2 → XP_038968927.1  transcription initiation factor IIA subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APY1
    Conserved Domains (1) summary
    pfam03153
    Location:1 → 338
    TFIIA; Transcription factor IIA, alpha/beta subunit

  3. XM_039113000.2 → XP_038968928.1  transcription initiation factor IIA subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APY1
    Related
    ENSRNOP00000086237.1
    Conserved Domains (1) summary
    pfam03153
    Location:1 → 338
    TFIIA; Transcription factor IIA, alpha/beta subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08949.1 GenPept UniProtKB/Swiss-Prot:O08949

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous