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Robo2 roundabout guidance receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84409, updated on 25-Apr-2024

Summary

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Official Symbol
Robo2provided by RGD
Official Full Name
roundabout guidance receptor 2provided by RGD
Primary source
RGD:620167
See related
Ensembl:ENSRNOG00000029598 AllianceGenome:RGD:620167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables axon guidance receptor activity. Involved in axon guidance; brain development; and spinal cord development. Predicted to be located in axolemma and cell surface. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 136.1), Lung (RPKM 47.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Robo2 in Genome Data Viewer
Location:
11p11
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (26015919..27583750, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (12528949..14096726, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (11062866..12618793, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene igE-binding protein-like Neighboring gene uncharacterized LOC134480951 Neighboring gene uncharacterized LOC120095537 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480952 Neighboring gene transfer RNA alanine (anticodon AGC) 31 Neighboring gene terminal nucleotidyltransferase 5B, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA binding motif protein 11 Neighboring gene lipase I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor. Zhang HY, et al. J Chem Neuroanat, 2010 Jul. PMID 20172023
  2. Alternatively spliced Robo2 isoforms in zebrafish and rat. Dalkic E, et al. Dev Genes Evol, 2006 Sep. PMID 16625395
  3. Regulation of cortical dendrite development by Slit-Robo interactions. Whitford KL, et al. Neuron, 2002 Jan 3. PMID 11779479
  4. ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia. Gonçalves AN, et al. Respir Res, 2020 Nov 18. PMID 33208157, Free PMC Article
  5. Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. Nguyen Ba-Charvet KT, et al. J Neurosci, 2001 Jun 15. PMID 11404413, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia.
    Title: ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia.
  2. data revealed a selective and sustained induction of Slit2 and Robo in astrocytes localized throughout the astroglial scar after ischemic stroke, suggesting that Slit2/Robo signaling participates in glial scar formation and brain remodeling following ischemic injury.
    Title: Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats.
  3. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract
    Title: Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.
  4. These findings indicate that Slit1/Robo2 signaling may have a role in regulating peripheral nerve regeneration.
    Title: Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor.
  5. Data show that at the stage of cerebellofugal axon midline crossing, mRNAs of Robo1 and Robo2 are expressed in the nuclear transitory zone of the cerebellum.
    Title: Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing.
  6. These results suggest that the alternatively spliced robo2 isoforms may exhibit tissue specificity.
    Title: Alternatively spliced Robo2 isoforms in zebrafish and rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables axon guidance receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aorta development ISO
Inferred from Sequence Orthology
more info
  
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process involved in luteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in axon midline choice point recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
  
involved_in heart induction ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metanephros development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of negative chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in olfactory bulb interneuron development ISO
Inferred from Sequence Orthology
more info
  
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in spinal cord development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in synapse maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axolemma ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
roundabout homolog 2
Names
roundabout 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415038.1 → NP_001401967.1  roundabout homolog 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    Related
    ENSRNOP00000076252.2, ENSRNOT00000093706.2

  2. NM_032106.4 → NP_115289.2  roundabout homolog 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A1W2Q6F3
    Related
    ENSRNOP00000070966.2, ENSRNOT00000088878.2
    Conserved Domains (6) summary
    cd00063
    Location:522 → 615
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:136 → 139
    Ig; Ig strand A [structural motif]
    cd05726
    Location:315 → 412
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:31 → 129
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:419 → 505
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:136 → 221
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    26015919..27583750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088674.2 → XP_038944602.1  roundabout homolog 2 isoform X4

    UniProtKB/TrEMBL
    F1M950
    Conserved Domains (6) summary
    cd00063
    Location:541 → 634
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:151 → 154
    Ig; Ig strand A [structural motif]
    cd05726
    Location:334 → 431
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:46 → 144
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:438 → 524
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:151 → 236
    Ig; Immunoglobulin domain

  2. XM_039088673.2 → XP_038944601.1  roundabout homolog 2 isoform X3

    UniProtKB/TrEMBL
    F1M950
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  3. XM_039088672.2 → XP_038944600.1  roundabout homolog 2 isoform X2

    UniProtKB/TrEMBL
    F1M950
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  4. XM_039088671.2 → XP_038944599.1  roundabout homolog 2 isoform X1

    UniProtKB/TrEMBL
    F1M950
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  5. XM_063270796.1 → XP_063126866.1  roundabout homolog 2 isoform X17

  6. XM_039088680.2 → XP_038944608.1  roundabout homolog 2 isoform X15

    UniProtKB/TrEMBL
    A0A8I6AKD6
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  7. XM_039088677.2 → XP_038944605.1  roundabout homolog 2 isoform X9

    UniProtKB/TrEMBL
    F1M950
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  8. XM_039088687.2 → XP_038944615.1  roundabout homolog 2 isoform X30

    UniProtKB/TrEMBL
    A0A8I6AKD6
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  9. XM_039088676.2 → XP_038944604.1  roundabout homolog 2 isoform X8

    UniProtKB/TrEMBL
    F1M950
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  10. XM_017598079.3 → XP_017453568.1  roundabout homolog 2 isoform X6

    UniProtKB/TrEMBL
    F1M950

  11. XM_063270795.1 → XP_063126865.1  roundabout homolog 2 isoform X12

  12. XM_039088679.2 → XP_038944607.1  roundabout homolog 2 isoform X11

    UniProtKB/TrEMBL
    A0A1W2Q6F3
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  13. XM_063270800.1 → XP_063126870.1  roundabout homolog 2 isoform X24

  14. XM_039088684.2 → XP_038944612.1  roundabout homolog 2 isoform X23

    UniProtKB/TrEMBL
    A0A8I6AKD6
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  15. XM_008768538.4 → XP_008766760.2  roundabout homolog 2 isoform X13

    UniProtKB/TrEMBL
    F1M950

  16. XM_063270798.1 → XP_063126868.1  roundabout homolog 2 isoform X19

  17. XM_063270797.1 → XP_063126867.1  roundabout homolog 2 isoform X18

  18. XM_039088681.2 → XP_038944609.1  roundabout homolog 2 isoform X16

    UniProtKB/TrEMBL
    A0A1W2Q6F3
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  19. XM_017598082.3 → XP_017453571.1  roundabout homolog 2 isoform X14

    UniProtKB/TrEMBL
    A0A1W2Q6F3

  20. XM_017598084.3 → XP_017453573.1  roundabout homolog 2 isoform X25

    UniProtKB/TrEMBL
    A0A8I6AKD6

  21. XM_063270802.1 → XP_063126872.1  roundabout homolog 2 isoform X29

  22. XM_063270801.1 → XP_063126871.1  roundabout homolog 2 isoform X28

  23. XM_039088686.2 → XP_038944614.1  roundabout homolog 2 isoform X27

    UniProtKB/TrEMBL
    A0A8I6A1P7
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  24. XM_039088685.2 → XP_038944613.1  roundabout homolog 2 isoform X26

    UniProtKB/TrEMBL
    A0A8I6AKD6
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  25. XM_039088683.2 → XP_038944611.1  roundabout homolog 2 isoform X22

    UniProtKB/TrEMBL
    A0A0G2JZA1
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  26. XM_039088689.2 → XP_038944617.1  roundabout homolog 2 isoform X34

    UniProtKB/TrEMBL
    A0A8I6AKD6
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  27. XM_063270799.1 → XP_063126869.1  roundabout homolog 2 isoform X21

  28. XM_039088682.2 → XP_038944610.1  roundabout homolog 2 isoform X20

    UniProtKB/TrEMBL
    A0A0G2JZA1
    Conserved Domains (6) summary
    cd00063
    Location:549 → 642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:342 → 439
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:446 → 532
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  29. XM_039088688.2 → XP_038944616.1  roundabout homolog 2 isoform X33

    UniProtKB/TrEMBL
    A0A8I6A1P7
    Conserved Domains (6) summary
    cd00063
    Location:545 → 638
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:159 → 162
    Ig; Ig strand A [structural motif]
    cd05726
    Location:338 → 435
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:54 → 152
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:442 → 528
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:159 → 244
    Ig; Immunoglobulin domain

  30. XM_063270803.1 → XP_063126873.1  roundabout homolog 2 isoform X32

  31. XM_008768539.4 → XP_008766761.2  roundabout homolog 2 isoform X31

    UniProtKB/TrEMBL
    A0A8I6AKD6
    Related
    ENSRNOP00000089188.1

  32. XM_039088678.2 → XP_038944606.1  roundabout homolog 2 isoform X10

    UniProtKB/TrEMBL
    F1M950
    Conserved Domains (6) summary
    cd00063
    Location:522 → 615
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:136 → 139
    Ig; Ig strand A [structural motif]
    cd05726
    Location:315 → 412
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:31 → 129
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:419 → 505
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:136 → 221
    Ig; Immunoglobulin domain

  33. XM_063270794.1 → XP_063126864.1  roundabout homolog 2 isoform X7

  34. XM_039088675.2 → XP_038944603.1  roundabout homolog 2 isoform X5

    UniProtKB/TrEMBL
    F1M950
    Related
    ENSRNOP00000061003.4
    Conserved Domains (6) summary
    cd00063
    Location:526 → 619
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:136 → 139
    Ig; Ig strand A [structural motif]
    cd05726
    Location:319 → 416
    IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
    cd07693
    Location:31 → 129
    IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
    cd20952
    Location:423 → 509
    IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:136 → 221
    Ig; Immunoglobulin domain

  35. XM_063270804.1 → XP_063126874.1  roundabout homolog 2 isoform X35

Nucleotide Protein Strain
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