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Tec tec protein tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 84492, updated on 4-Jan-2025

Summary

Official Symbol
Tecprovided by RGD
Official Full Name
tec protein tyrosine kinaseprovided by RGD
Primary source
RGD:620973
See related
EnsemblRapid:ENSRNOG00000002278 AllianceGenome:RGD:620973
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in tissue regeneration. Predicted to be located in cell-cell junction and cytoskeleton. Predicted to be active in plasma membrane. Orthologous to human TEC (tec protein tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 121.4), Liver (RPKM 93.7) and 9 other tissues See more
Orthologs
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Genomic context

See Tec in Genome Data Viewer
Location:
14p11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35706557..35815563)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35352551..35461585)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (37918884..38027953)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SLAIN motif family, member 2 Neighboring gene glutathione peroxidase 4, pseudogene 3 Neighboring gene TXK tyrosine kinase Neighboring gene NIPA-like domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables metal ion binding  
enables non-membrane spanning protein tyrosine kinase activity  
enables non-membrane spanning protein tyrosine kinase activity  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway  
involved_in B cell receptor signaling pathway  
involved_in T cell receptor signaling pathway  
involved_in adaptive immune response  
involved_in chromatin remodeling  
involved_in integrin-mediated signaling pathway  
involved_in intracellular signal transduction  
involved_in regulation of platelet activation  
involved_in tissue regeneration PubMed 
Component Evidence Code Pubs
located_in cell-cell junction  
located_in cytoskeleton  
located_in cytosol  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
tyrosine-protein kinase Tec
Names
cytoplasmic tyrosine kinase, Dscr28C related
NP_445884.1
XP_038948440.1
XP_038948441.1
XP_038948442.1
XP_063129753.1
XP_063129754.1
XP_063129755.1
XP_063129756.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053432.1NP_445884.1  tyrosine-protein kinase Tec

    See identical proteins and their annotated locations for NP_445884.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166730
    UniProtKB/TrEMBL
    A0A8I5ZXG2, B2RYC7
    Related
    ENSRNOP00000003125.5, ENSRNOT00000003125.7
    Conserved Domains (4) summary
    cd10396
    Location:238345
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:181235
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:363622
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    35706557..35815563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273685.1XP_063129755.1  tyrosine-protein kinase Tec isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXG2, A0A8I6A3K6
  2. XM_039092512.2XP_038948440.1  tyrosine-protein kinase Tec isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZXG2, B2RYC7
    Related
    ENSRNOP00000075313.1, ENSRNOT00000088441.3
    Conserved Domains (4) summary
    cd10396
    Location:238345
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:181235
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cd05114
    Location:363622
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
  3. XM_063273683.1XP_063129753.1  tyrosine-protein kinase Tec isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXG2, A0A8I6A3K6
  4. XM_039092513.2XP_038948441.1  tyrosine-protein kinase Tec isoform X4

    Conserved Domains (4) summary
    cd10396
    Location:238345
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:181235
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd01238
    Location:7148
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    cl21453
    Location:363488
    PKc_like; Protein Kinases, catalytic domain
  5. XM_063273684.1XP_063129754.1  tyrosine-protein kinase Tec isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXG2, A0A8I6A3K6
  6. XM_063273686.1XP_063129756.1  tyrosine-protein kinase Tec isoform X3

    UniProtKB/TrEMBL
    Q9EQ78
  7. XM_039092514.2XP_038948442.1  tyrosine-protein kinase Tec isoform X5

    UniProtKB/TrEMBL
    Q9EQ78
    Conserved Domains (4) summary
    cd10396
    Location:156263
    SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
    cd11905
    Location:99153
    SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
    cd05114
    Location:281540
    PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
    cl17171
    Location:1066
    PH-like; Pleckstrin homology-like domain
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