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Rims1 regulating synaptic membrane exocytosis 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84556, updated on 2-May-2024

Summary

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Official Symbol
Rims1provided by RGD
Official Full Name
regulating synaptic membrane exocytosis 1provided by RGD
Primary source
RGD:620000
See related
Ensembl:ENSRNOG00000011000 AllianceGenome:RGD:620000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rim1; RIM1a
Summary
Enables SH3 domain binding activity; protein kinase binding activity; and small GTPase binding activity. Involved in long-term synaptic potentiation; positive regulation of inhibitory postsynaptic potential; and positive regulation of synaptic vesicle priming. Located in presynaptic membrane. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in cone-rod dystrophy 7. Orthologous to human RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 145.5), Uterus (RPKM 16.1) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
9q13
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (32193352..32692998, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (24696959..25196404, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (28440408..28973246, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480561 Neighboring gene ferritin light chain 1-like Neighboring gene KH domain containing 1B Neighboring gene potassium voltage-gated channel subfamily Q member 5 Neighboring gene uncharacterized LOC134480352 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 2 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14B like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A trans-synaptic nanocolumn aligns neurotransmitter release to receptors. Tang AH, et al. Nature, 2016 Aug 11. PMID 27462810, Free PMC Article
  2. RIM1α SUMOylation is required for fast synaptic vesicle exocytosis. Girach F, et al. Cell Rep, 2013 Dec 12. PMID 24290762, Free PMC Article
  3. Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution. Guan R, et al. Biochemistry, 2007 Aug 7. PMID 17630786, Free PMC Article
  4. RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation. Wu X, et al. Mol Cell, 2019 Mar 7. PMID 30661983
  5. A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing. Jiang X, et al. J Neurosci, 2010 Feb 3. PMID 20130189, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RIM1a and RIM-BP2 are plausible organizers of active zones, and the formation of RIM and RIM-BP condensates may cluster voltage gated calcium channels into nano- or microdomains and position the clustered Ca(2+) channels with Ca(2+) sensors on docked vesicles for efficient and precise synaptic transmissions.
    Title: RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation.
  2. RIM1alpha SUMOylation at K502 is required for its binding to Cav2.1 and for fast synaptic vesicle exocytosis.
    Title: RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.
  3. Depletion of liprin-alpha2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-alpha2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release.
    Title: Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
  4. Data show that Bassoon colocalizes with Aczonin at conventional synapses, but in ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, and Aczonin is positioned and may control the access of neurotransmitter vesicles to the fusion site.
    Title: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
  5. Presynaptic silencing was accompanied by decreases in levels of the priming proteins Munc13-1 and Rim1.
    Title: A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing.
  6. The crystal structure of the RIM1alpha C2B domain dimer reveals that it forms a beta-sandwich and that the unique N- and C-terminal extensions form a small subdomain that packs against the beta-sandwich and mediates dimerization.
    Title: Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.
  7. These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis.
    Title: Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
  8. RIM1- or Bassoon-binding region of CAST impairs synaptic transmission in cultured superior cervical ganglion neurons.
    Title: Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.
  9. Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
    Title: Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acrosomal vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of presynaptic active zone structure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of inhibitory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic vesicle fusion to presynaptic active zone membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of synaptic vesicle priming IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle docking ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulating synaptic membrane exocytosis protein 1
Names
RIM 1
Rab3 effector
Rim1b protein
rab-3-interacting molecule 1
rab3-interacting molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398595.2 → NP_001385524.1  regulating synaptic membrane exocytosis protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2JT77
    Related
    ENSRNOP00000068599.2, ENSRNOT00000091865.2
    Conserved Domains (7) summary
    cd04028
    Location:1445 → 1590
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:887 → 1207
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  2. NM_052829.4 → NP_439894.2  regulating synaptic membrane exocytosis protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Related
    ENSRNOP00000075220.2, ENSRNOT00000079684.2
    Conserved Domains (6) summary
    cd04028
    Location:1384 → 1529
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    32193352..32692998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267779.1 → XP_063123849.1  regulating synaptic membrane exocytosis protein 1 isoform X9

  2. XM_017596679.3 → XP_017452168.2  regulating synaptic membrane exocytosis protein 1 isoform X42

    UniProtKB/TrEMBL
    F1LYS1
    Conserved Domains (8) summary
    cd04028
    Location:1247 → 1392
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:702 → 828
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:379 → 496
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:877 → 1176
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:564 → 649
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:160 → 262
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:104 → 155
    FYVE_like_SF; FYVE domain like superfamily
    cl22851
    Location:26 → 149
    PHD_SF; PHD finger superfamily

  3. XM_039084268.2 → XP_038940196.1  regulating synaptic membrane exocytosis protein 1 isoform X10

    UniProtKB/TrEMBL
    F1LYS1
    Related
    ENSRNOP00000015454.7
    Conserved Domains (8) summary
    cd04028
    Location:1419 → 1564
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:702 → 828
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:379 → 496
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:833 → 1187
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:564 → 649
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:160 → 262
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:104 → 155
    FYVE_like_SF; FYVE domain like superfamily
    cl22851
    Location:26 → 149
    PHD_SF; PHD finger superfamily

  4. XM_039084294.2 → XP_038940222.1  regulating synaptic membrane exocytosis protein 1 isoform X41

    UniProtKB/TrEMBL
    F1LYS1
    Conserved Domains (8) summary
    cd04028
    Location:1251 → 1396
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:706 → 832
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:383 → 500
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:881 → 1180
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:568 → 653
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:164 → 266
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:104 → 159
    FYVE_like_SF; FYVE domain like superfamily
    cl22851
    Location:26 → 153
    PHD_SF; PHD finger superfamily

  5. XM_017596678.3 → XP_017452167.2  regulating synaptic membrane exocytosis protein 1 isoform X8

    UniProtKB/TrEMBL
    F1LYS1
    Conserved Domains (8) summary
    cd04028
    Location:1423 → 1568
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:706 → 832
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:383 → 500
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:837 → 1191
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:568 → 653
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:164 → 266
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:104 → 159
    FYVE_like_SF; FYVE domain like superfamily
    cl22851
    Location:26 → 153
    PHD_SF; PHD finger superfamily

  6. XM_039084265.2 → XP_038940193.1  regulating synaptic membrane exocytosis protein 1 isoform X7

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1446 → 1591
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:729 → 855
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:406 → 523
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:860 → 1214
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:591 → 676
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:187 → 289
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:127 → 182
    FYVE_like_SF; FYVE domain like superfamily

  7. XM_039084263.2 → XP_038940191.1  regulating synaptic membrane exocytosis protein 1 isoform X5

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1449 → 1594
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:732 → 858
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:409 → 526
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:863 → 1217
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:594 → 679
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:190 → 292
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:130 → 185
    FYVE_like_SF; FYVE domain like superfamily

  8. XM_063267781.1 → XP_063123851.1  regulating synaptic membrane exocytosis protein 1 isoform X19

  9. XM_039084261.2 → XP_038940189.1  regulating synaptic membrane exocytosis protein 1 isoform X4

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1450 → 1595
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:733 → 859
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:410 → 527
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:864 → 1218
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:595 → 680
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:191 → 293
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:131 → 186
    FYVE_like_SF; FYVE domain like superfamily

  10. XM_039084259.2 → XP_038940187.1  regulating synaptic membrane exocytosis protein 1 isoform X2

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1469 → 1614
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:752 → 878
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:429 → 546
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:883 → 1237
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:614 → 699
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:210 → 312
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 205
    FYVE_like_SF; FYVE domain like superfamily

  11. XM_039084264.2 → XP_038940192.1  regulating synaptic membrane exocytosis protein 1 isoform X6

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1449 → 1594
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:955 → 1217
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  12. XM_039084287.2 → XP_038940215.1  regulating synaptic membrane exocytosis protein 1 isoform X34

    UniProtKB/TrEMBL
    A0A8I6GLS3
    Conserved Domains (6) summary
    cd04028
    Location:1137 → 1282
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  13. XM_039084279.2 → XP_038940207.1  regulating synaptic membrane exocytosis protein 1 isoform X25

    UniProtKB/TrEMBL
    A0A8I6GLS3
    Conserved Domains (6) summary
    cd04028
    Location:1300 → 1445
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  14. XM_017596670.3 → XP_017452159.2  regulating synaptic membrane exocytosis protein 1 isoform X23

    UniProtKB/TrEMBL
    A0A8I6GLS3
    Related
    ENSRNOP00000095741.1
    Conserved Domains (6) summary
    cd04028
    Location:1309 → 1454
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  15. XM_039084275.2 → XP_038940203.1  regulating synaptic membrane exocytosis protein 1 isoform X16

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (6) summary
    cd04028
    Location:1370 → 1515
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  16. XM_039084285.2 → XP_038940213.1  regulating synaptic membrane exocytosis protein 1 isoform X32

    UniProtKB/TrEMBL
    A0A8I6GLS3
    Conserved Domains (6) summary
    cd04028
    Location:1161 → 1306
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  17. XM_039084277.2 → XP_038940205.1  regulating synaptic membrane exocytosis protein 1 isoform X20

    UniProtKB/TrEMBL
    A0A8I6GLS3
    Conserved Domains (6) summary
    cd04028
    Location:1333 → 1478
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  18. XM_039084271.2 → XP_038940199.1  regulating synaptic membrane exocytosis protein 1 isoform X13

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1394 → 1539
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03381
    Location:999 → 1130
    PHA03381; tegument protein VP22; Provisional
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  19. XM_039084286.2 → XP_038940214.1  regulating synaptic membrane exocytosis protein 1 isoform X33

    UniProtKB/TrEMBL
    A0A8I6GLS3
    Conserved Domains (6) summary
    cd04028
    Location:1158 → 1303
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  20. XM_063267782.1 → XP_063123852.1  regulating synaptic membrane exocytosis protein 1 isoform X22

  21. XM_039084278.2 → XP_038940206.1  regulating synaptic membrane exocytosis protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A8I6GLS3
    Conserved Domains (6) summary
    cd04028
    Location:1330 → 1475
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  22. XM_017596673.3 → XP_017452162.2  regulating synaptic membrane exocytosis protein 1 isoform X31

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (6) summary
    cd04028
    Location:1188 → 1333
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  23. XM_039084276.2 → XP_038940204.1  regulating synaptic membrane exocytosis protein 1 isoform X18

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (6) summary
    cd04028
    Location:1351 → 1496
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  24. XM_017596667.3 → XP_017452156.2  regulating synaptic membrane exocytosis protein 1 isoform X17

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (6) summary
    cd04028
    Location:1360 → 1505
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  25. XM_017596672.3 → XP_017452161.2  regulating synaptic membrane exocytosis protein 1 isoform X30

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (6) summary
    cd04028
    Location:1212 → 1357
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  26. XM_039084274.2 → XP_038940202.1  regulating synaptic membrane exocytosis protein 1 isoform X15

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (6) summary
    cd04028
    Location:1375 → 1520
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  27. XM_039084282.2 → XP_038940210.1  regulating synaptic membrane exocytosis protein 1 isoform X27

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1273 → 1418
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:887 → 1202
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  28. XM_063267785.1 → XP_063123855.1  regulating synaptic membrane exocytosis protein 1 isoform X29

  29. XM_039084273.2 → XP_038940201.1  regulating synaptic membrane exocytosis protein 1 isoform X14

    UniProtKB/TrEMBL
    F1LYS1
    Conserved Domains (7) summary
    cd04028
    Location:1388 → 1533
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA02666
    Location:940 → 1129
    PHA02666; hypothetical protein; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  30. XM_039084283.2 → XP_038940211.1  regulating synaptic membrane exocytosis protein 1 isoform X28

    UniProtKB/TrEMBL
    F1LYS1
    Conserved Domains (7) summary
    cd04028
    Location:1240 → 1385
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:885 → 1154
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  31. XM_039084270.2 → XP_038940198.1  regulating synaptic membrane exocytosis protein 1 isoform X12

    UniProtKB/TrEMBL
    F1LYS1
    Conserved Domains (7) summary
    cd04028
    Location:1403 → 1548
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:885 → 1154
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  32. XM_039084269.2 → XP_038940197.1  regulating synaptic membrane exocytosis protein 1 isoform X11

    UniProtKB/TrEMBL
    F1LYS1
    Conserved Domains (7) summary
    cd04028
    Location:1412 → 1557
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:885 → 1154
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  33. XM_017596671.3 → XP_017452160.2  regulating synaptic membrane exocytosis protein 1 isoform X24

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1301 → 1446
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:931 → 1230
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  34. XM_039084260.2 → XP_038940188.1  regulating synaptic membrane exocytosis protein 1 isoform X3

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1464 → 1609
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:887 → 1241
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  35. XM_017596657.3 → XP_017452146.2  regulating synaptic membrane exocytosis protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O35168, Q9JIR4
    Conserved Domains (7) summary
    cd04028
    Location:1473 → 1618
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:887 → 1241
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

  36. XM_063267783.1 → XP_063123853.1  regulating synaptic membrane exocytosis protein 1 isoform X26

  37. XM_039084290.2 → XP_038940218.1  regulating synaptic membrane exocytosis protein 1 isoform X36

    UniProtKB/TrEMBL
    A6JJA0
    Conserved Domains (4) summary
    cd04028
    Location:938 → 1083
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:221 → 347
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:352 → 706
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:83 → 168
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  38. XM_039084292.2 → XP_038940220.1  regulating synaptic membrane exocytosis protein 1 isoform X38

    UniProtKB/TrEMBL
    A6JJA0
    Conserved Domains (4) summary
    cd04028
    Location:852 → 997
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:135 → 261
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:266 → 620
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:1 → 82
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  39. XM_039084291.2 → XP_038940219.1  regulating synaptic membrane exocytosis protein 1 isoform X37

    UniProtKB/TrEMBL
    A6JJA0
    Conserved Domains (4) summary
    cd04028
    Location:903 → 1048
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
    cd04031
    Location:186 → 312
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PHA03307
    Location:317 → 671
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:48 → 133
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  40. XM_039084293.2 → XP_038940221.1  regulating synaptic membrane exocytosis protein 1 isoform X39

    Conserved Domains (1) summary
    cd04028
    Location:229 → 374
    C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

  41. XM_063267786.1 → XP_063123856.1  regulating synaptic membrane exocytosis protein 1 isoform X40

  42. XM_039084288.2 → XP_038940216.1  regulating synaptic membrane exocytosis protein 1 isoform X35

    Conserved Domains (6) summary
    cd04031
    Location:756 → 882
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    PLN03237
    Location:433 → 550
    PLN03237; DNA topoisomerase 2; Provisional
    PHA03307
    Location:887 → 1241
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:618 → 703
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04642
    Location:214 → 316
    DUF601; Protein of unknown function, DUF601
    cl28890
    Location:154 → 209
    FYVE_like_SF; FYVE domain like superfamily

RNA

  1. XR_010054639.1 RNA Sequence

  2. XR_010054638.1 RNA Sequence

  3. XR_010054637.1 RNA Sequence

  4. XR_010054636.1 RNA Sequence

  5. XR_005488976.2 RNA Sequence

  6. XR_005488975.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIR4.1 GenPept UniProtKB/Swiss-Prot:Q9JIR4

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