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PRRC2B proline rich coiled-coil 2B [ Homo sapiens (human) ]

Gene ID: 84726, updated on 5-May-2024

Summary

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Official Symbol
PRRC2Bprovided by HGNC
Official Full Name
proline rich coiled-coil 2Bprovided by HGNC
Primary source
HGNC:HGNC:28121
See related
Ensembl:ENSG00000288701 MIM:619544; AllianceGenome:HGNC:28121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAT2L; BAT2L1; LQFBS-1; KIAA0515
Summary
Enables RNA binding activity. Predicted to be involved in cell differentiation. Predicted to act upstream of or within in utero embryonic development. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 18.3), ovary (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9q34.13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131373651..131500193)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143583138..143713087)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134249038..134375580)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134176375-134176876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134176877-134177376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20412 Neighboring gene phospholipid phosphatase 7 (inactive) Neighboring gene ReSE screen-validated silencer GRCh37_chr9:134197285-134197821 Neighboring gene uncharacterized LOC105376299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134205514-134206468 Neighboring gene uncharacterized LOC105376300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134227487-134227988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134230857-134231474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134231475-134232090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134234556-134235172 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134248209-134248730 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134248731-134249254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134269973-134270734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134271497-134272258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134276654-134277645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134284252-134284752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29189 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134311463-134312438 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134312439-134313412 Neighboring gene Sharpr-MPRA regulatory region 9532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134364584-134365084 Neighboring gene small nucleolar RNA, C/D box 62A Neighboring gene uncharacterized LOC124902290 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134375403-134376602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378091-134378958 Neighboring gene small nucleolar RNA, C/D box 62B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378959-134379824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388206-134388706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388707-134389207 Neighboring gene uncharacterized LOC105376301 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134403902-134405101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134405807-134406720 Neighboring gene protein O-mannosyltransferase 1 Neighboring gene uridine-cytidine kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression. Jiang F, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37125639, Free PMC Article
  2. Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, et al. Genome Res, 2016 Sep. PMID 27365365, Free PMC Article
  3. EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway. Xie C, et al. Biomed Res Int, 2020. PMID 33029523, Free PMC Article
  4. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. Vasilescu J, et al. J Proteome Res, 2007 Jan. PMID 17203973
  5. BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility. Manjur ABMK, et al. J Steroid Biochem Mol Biol, 2021 Jun. PMID 33722704

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis.
    Title: Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis.
  2. RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression.
    Title: RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0515, MGC10526, DKFZp781F05101, DKFZp781K12107

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein PRRC2B
Names
HLA-B associated transcript 2-like
HLA-B-associated transcript 2-like 1
proline-rich coiled-coil protein 2B
protein BAT2-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384818.1 → NP_001371747.1  protein PRRC2B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL354855, AL358781
    Consensus CDS
    CCDS48044.1
    UniProtKB/Swiss-Prot
    O60270, Q5JSZ5, Q5JSZ7, Q66VZ2, Q68CR0, Q96EI9, Q9H683
    Related
    ENSP00000508005.1, ENST00000684596.1
    Conserved Domains (2) summary
    pfam03154
    Location:1866 → 2175
    Atrophin-1; Atrophin-1 family
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  2. NM_001384821.1 → NP_001371750.1  protein PRRC2B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL354855, AL358781
    Conserved Domains (2) summary
    pfam03154
    Location:1865 → 2174
    Atrophin-1; Atrophin-1 family
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  3. NM_001384822.1 → NP_001371751.1  protein PRRC2B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL354855, AL358781
    Conserved Domains (2) summary
    pfam03154
    Location:1865 → 2154
    Atrophin-1; Atrophin-1 family
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  4. NM_001384823.1 → NP_001371752.1  protein PRRC2B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL354855, AL358781
    Related
    ENSP00000508073.1, ENST00000682501.1
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  5. NM_013318.4 → NP_037450.2  protein PRRC2B isoform 1

    See identical proteins and their annotated locations for NP_037450.2

    Status: VALIDATED

    Source sequence(s)
    AL354855, AL358781
    Consensus CDS
    CCDS48044.1
    UniProtKB/Swiss-Prot
    O60270, Q5JSZ5, Q5JSZ7, Q66VZ2, Q68CR0, Q96EI9, Q9H683
    Related
    ENSP00000508048.1, ENST00000683519.1
    Conserved Domains (2) summary
    pfam03154
    Location:1866 → 2175
    Atrophin-1; Atrophin-1 family
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    131373651..131500193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143583138..143713087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032640.2: Suppressed sequence

    Description
    NM_032640.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JSZ5.2 GenPept UniProtKB/Swiss-Prot:Q5JSZ5

Gene LinkOut

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