U.S. flag

An official website of the United States government

CIT2 citrate (Si)-synthase CIT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850361, updated on 4-Jan-2025

Summary

Official Symbol
CIT2
Official Full Name
citrate (Si)-synthase CIT2
Primary source
SGD:S000000598
Locus tag
YCR005C
See related
AllianceGenome:SGD:S000000598; FungiDB:YCR005C; VEuPathDB:YCR005C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables citrate (Si)-synthase activity. Involved in citrate metabolic process. Located in peroxisome. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CIT2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (120946..122328, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL32 Neighboring gene flavodoxin-like fold family protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

Genomic Sequence:
NC_001135.5

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables citrate (Si)-synthase activity  
enables citrate (Si)-synthase activity PubMed 
enables citrate (Si)-synthase activity  
enables citrate (Si)-synthase activity PubMed 
enables citrate synthase activity  
enables transferase activity  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process  
involved_in citrate metabolic process  
involved_in citrate metabolic process PubMed 
involved_in tricarboxylic acid cycle  
involved_in tricarboxylic acid cycle  
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytoplasm  
is_active_in mitochondrial matrix  
located_in mitochondrion PubMed 
located_in peroxisome PubMed 
located_in peroxisome  

General protein information

Preferred Names
citrate (Si)-synthase CIT2
NP_009931.1
  • Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    120946..122328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178718.1NP_009931.1  TPA: citrate (Si)-synthase CIT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009931.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR15, P08679
    UniProtKB/TrEMBL
    A6ZTI7, B3LU77, B5VEV3, C7GQL8, C8Z490, G2WA23, N1P997
    Conserved Domains (1) summary
    cl00416
    Location:26452
    CS_ACL-C_CCL; Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A ...
External link. Please review our privacy policy.