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NPP1 nucleotide diphosphatase/phosphodiesterase NPP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850391, updated on 4-Jan-2025

Summary

Official Symbol
NPP1
Official Full Name
nucleotide diphosphatase/phosphodiesterase NPP1
Primary source
SGD:S000000621
Locus tag
YCR026C
See related
AllianceGenome:SGD:S000000621; FungiDB:YCR026C; VEuPathDB:YCR026C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nucleoside triphosphate diphosphatase activity and ribonucleoside triphosphate phosphatase activity. Involved in cellular response to phosphate starvation and nucleoside triphosphate metabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to several human genes including ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4) and ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See NPP1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (164111..166339, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene proteolipid ATPase Neighboring gene uncharacterized protein Neighboring gene putative GTPase RHB1 Neighboring gene tRNA-Gln

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
is_active_in cellular_component  
located_in membrane  

General protein information

Preferred Names
nucleotide diphosphatase/phosphodiesterase NPP1
NP_009955.2
  • Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    164111..166339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178741.1NP_009955.2  TPA: nucleotide diphosphatase/phosphodiesterase NPP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009955.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR36, P25353, Q8NIL9
    UniProtKB/TrEMBL
    G2WA44, N1P7V5
    Conserved Domains (1) summary
    pfam01663
    Location:170545
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
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