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TRX3 Trx3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850444, updated on 17-May-2024

Summary

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Gene symbol
TRX3
Gene description
Trx3p
Primary source
FungiDB:YCR083W
Locus tag
YCR083W
See related
SGD:S000000679; AllianceGenome:SGD:S000000679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables disulfide oxidoreductase activity. Involved in cellular response to oxidative stress. Located in mitochondrion. Orthologous to several human genes including TXN (thioredoxin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TRX3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (259578..259961)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Srb8p Neighboring gene Ahc2p Neighboring gene chromatin-silencing transcriptional regulator TUP1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues. Bao R, et al. Biochim Biophys Acta, 2009 Apr. PMID 19166985
  2. Expression, purification, crystallization and preliminary X-ray diffraction analysis of mitochondrial thioredoxin Trx3 from Saccharomyces cerevisiae. Bao R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Nov 1. PMID 17077505, Free PMC Article
  3. Mitochondrial 1-Cys-peroxiredoxin/thioredoxin system protects manganese-containing superoxide dismutase (Mn-SOD) against inactivation by peroxynitrite in Saccharomyces cerevisiae. Pedrajas JR, et al. Nitric Oxide, 2010 Nov 1. PMID 20547232
  4. Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin. Zhang Z, et al. Biochim Biophys Acta, 2009 Jan. PMID 18930846
  5. Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. Pedrajas JR, et al. J Biol Chem, 2000 May 26. PMID 10821871

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial Prx1 functions as a redox signaling molecule that oxidizes Trx3 and promotes apoptosis.
    Title: Oxidation of the yeast mitochondrial thioredoxin promotes cell death.
  2. crystal structures of yeast Trx3 in oxidized and reduced forms at 1.80 & 2.10 A, respectively; findings providesome new insights into the putative function of the additional cysteine residues of Trx3
    Title: Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues.
  3. S. cerevisiae Trx3 was overexpressed in Escherichia coli was purified and crystallized and xray diffraction performed.
    Title: Expression, purification, crystallization and preliminary X-ray diffraction analysis of mitochondrial thioredoxin Trx3 from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Trx3p
NP_010006.1
  • Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    259578..259961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178789.1 → NP_010006.1  TPA: Trx3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010006.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR84, P25372
    UniProtKB/TrEMBL
    A0A6A5Q1E0, A6ZTQ5, B3LUD7, C7GUW5, C8Z4H0, G2WA91, N1P7Q3
    Conserved Domains (1) summary
    cd02947
    Location:35 → 125
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25372.1

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