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SDH2 succinate dehydrogenase iron-sulfur protein subunit SDH2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850685, updated on 11-Apr-2024

Summary

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Gene symbol
SDH2
Gene description
succinate dehydrogenase iron-sulfur protein subunit SDH2
Primary source
SGD:S000003964
Locus tag
YLL041C
See related
AllianceGenome:SGD:S000003964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACN17
Summary
Enables succinate dehydrogenase (ubiquinone) activity. Involved in tricarboxylic acid cycle. Located in mitochondrial membrane. Part of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Colocalizes with fungal-type vacuole membrane. Used to study mitochondrial encephalomyopathy and paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (53131..53931, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fps1p Neighboring gene E2-like conjugating enzyme Neighboring gene membrane morphogenesis protein VPS13 Neighboring gene ubiquitin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. Goffrini P, et al. Hum Mol Genet, 2009 May 15. PMID 19261679
  2. The role of the 5' untranslated region (UTR) in glucose-dependent mRNA decay. de la Cruz BJ, et al. Yeast, 2002 Jul. PMID 12112242
  3. Genetic analysis of glucose regulation in saccharomyces cerevisiae: control of transcription versus mRNA turnover. Cereghino GP, et al. EMBO J, 1996 Jan 15. PMID 8617211, Free PMC Article
  4. Glucose-dependent turnover of the mRNAs encoding succinate dehydrogenase peptides in Saccharomyces cerevisiae: sequence elements in the 5' untranslated region of the Ip mRNA play a dominant role. Cereghino GP, et al. Mol Biol Cell, 1995 Sep. PMID 8534911, Free PMC Article
  5. Studies on the assembly of complex II in yeast mitochondria using chimeric human/yeast genes for the iron-sulfur protein subunit. Saghbini M, et al. Biochemistry, 1994 Jan 11. PMID 8286334

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 3 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate dehydrogenase (quinone) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables succinate dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular respiration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
succinate dehydrogenase iron-sulfur protein subunit SDH2
NP_013059.1
  • Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    53131..53931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181861.1 → NP_013059.1  TPA: succinate dehydrogenase iron-sulfur protein subunit SDH2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013059.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXW5, P21801
    UniProtKB/TrEMBL
    A0A6A5PS64, A7A0L7, B3LTD3, B5VMQ7, C7GRK0, C8ZCT3, G2WIF6, N1NZC0
    Conserved Domains (1) summary
    PLN00129
    Location:31 → 264
    PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21801.1

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