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XYL2 D-xylulose reductase XYL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850759, updated on 13-Apr-2024

Summary

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Gene symbol
XYL2
Gene description
D-xylulose reductase XYL2
Primary source
SGD:S000004060
Locus tag
YLR070C
See related
AllianceGenome:SGD:S000004060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-xylulose reductase activity. Involved in xylulose biosynthetic process. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (274141..275211, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fyv7p Neighboring gene Mef1p Neighboring gene Rgr1p Neighboring gene Lam6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Repeated-batch fermentations of xylose and glucose-xylose mixtures using a respiration-deficient Saccharomyces cerevisiae engineered for xylose metabolism. Kim SR, et al. J Biotechnol, 2010 Nov. PMID 20933550
  2. Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase. Richard P, et al. FEBS Lett, 1999 Aug 20. PMID 10486580
  3. Expression of different levels of enzymes from the Pichia stipitis XYL1 and XYL2 genes in Saccharomyces cerevisiae and its effects on product formation during xylose utilisation. Walfridsson M, et al. Appl Microbiol Biotechnol, 1997 Aug. PMID 9299780
  4. Optimizing the coordinated transcription of central xylose-metabolism genes in Saccharomyces cerevisiae. Zhang X, et al. Appl Microbiol Biotechnol, 2018 Aug. PMID 29946930
  5. Impact of overexpressing NADH kinase on glucose and xylose metabolism in recombinant xylose-utilizing Saccharomyces cerevisiae. Hou J, et al. Appl Microbiol Biotechnol, 2009 Apr. PMID 19221731

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-xylulose reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-xylulose reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-iditol 2-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-xylose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-arabinose catabolic process to xylulose 5-phosphate IEA
Inferred from Electronic Annotation
more info
  
involved_in sorbitol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xylulose biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
D-xylulose reductase XYL2
NP_013171.1
  • Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    274141..275211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181957.1 → NP_013171.1  TPA: D-xylulose reductase XYL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY71, Q07993
    UniProtKB/TrEMBL
    A0A8H4F9T8, A7A0X5, B3LT40, B5VN02, C7GQP5, C8ZD42, G2WIR2, N1NZI2
    Conserved Domains (1) summary
    cd05285
    Location:9 → 354
    sorbitol_DH; Sorbitol dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07993.1

Gene LinkOut

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