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ERG27 3-keto-steroid reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850790, updated on 5-May-2024

Summary

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Gene symbol
ERG27
Gene description
3-keto-steroid reductase
Primary source
SGD:S000004090
Locus tag
YLR100W
See related
AllianceGenome:SGD:S000004090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-keto sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and lipid droplet. Used to study steroid inherited metabolic disorder. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (341810..342853)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid acyltransferase ICT1 Neighboring gene Mim2p Neighboring gene anaphase promoting complex subunit 9 Neighboring gene DNA replication initiation factor CDC45

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast. Yang C, et al. Phytochemistry, 2018 Nov. PMID 30077898
  2. 4-Methylzymosterone and Other Intermediates of Sterol Biosynthesis from Yeast Mutants Engineered in the ERG27 Gene Encoding 3-Ketosteroid Reductase. Ferrante T, et al. Lipids, 2016 Sep. PMID 27421732
  3. Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. Gachotte D, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10535978, Free PMC Article
  4. Difference in the late ergosterol biosynthesis between yeast spheroplasts and intact cells. Ferrante T, et al. Acta Biochim Pol, 2016. PMID 27031513
  5. Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. Taramino S, et al. Biochim Biophys Acta, 2010 Nov. PMID 20659585, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast; results will help elucidate the biosynthetic pathways of ganoderic acids
    Title: Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast.
  2. This study provides new insights into the role of Erg27p in sterol biosynthesis.
    Title: Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-keto sterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-keto sterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-keto sterol reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane HDA PubMed 

General protein information

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Preferred Names
3-keto-steroid reductase
NP_013201.1
  • 3-keto sterol reductase; catalyzes last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; Erg27 protein is mainly ER-localized in strains devoid of mtDNA (rho cells); mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    341810..342853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181987.1 → NP_013201.1  TPA: 3-keto-steroid reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013201.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYA1, Q12452
    UniProtKB/TrEMBL
    A0A8H4F8D8, B3LT69, C7GQS4, C8ZD71, G2WIU4, N1NY57
    Conserved Domains (1) summary
    cd08941
    Location:3 → 293
    3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12452.1

Gene LinkOut

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