PUT1 proline dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PUT1
Gene description: proline dehydrogenase
Primary source: SGD:S000004132
Locus tag: YLR142W
See related: AllianceGenome:SGD:S000004132
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables proline dehydrogenase activity. Involved in proline catabolic process to glutamate. Located in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1) and PRODH2 (proline dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (425186..426616)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Purification and characterization of Put1p from Saccharomyces cerevisiae.
Title: Purification and characterization of Put1p from Saccharomyces cerevisiae.
The phosphorylation of Put3p appears to influence the association of Gat1p, but not Gln3p, to the PUT1 promoter.
Title: Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables proline dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables proline dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables proline dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in proline catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proline catabolic process to glutamate	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline catabolic process to glutamate	IDA Inferred from Direct Assay more info	PubMed
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
involved_in proline catabolic process to glutamate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proline metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proline dehydrogenase

NP_013243.1

EC 1.5.5.2

Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

425186..426616

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182029.1 → NP_013243.1 TPA: proline dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013243.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYD6, P09368

UniProtKB/TrEMBL

A0A8H4BY43, A7A140, G2WIY0, N1NZQ2

Conserved Domains (1) summary

COG0506
Location:35 → 467

PutA; Proline dehydrogenase [Amino acid transport and metabolism]