SHH4 protein SHH4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: SHH4
Gene description: protein SHH4
Primary source: SGD:S000004154
Locus tag: YLR164W
See related: AllianceGenome:SGD:S000004154
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to succinate dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Used to study paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquinone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	IGI Inferred from Genetic Interaction more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_013265.1

Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p