IDP2 isocitrate dehydrogenase (NADP(+)) IDP2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: IDP2
Gene description: isocitrate dehydrogenase (NADP(+)) IDP2
Primary source: FungiDB:YLR174W
Locus tag: YLR174W
See related: SGD:S000004164; AllianceGenome:SGD:S000004164
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables isocitrate dehydrogenase (NADP+) activity. Involved in isocitrate metabolic process. Located in cytosol. Used to study high grade glioma. Human ortholog(s) of this gene implicated in several diseases, including D-2-hydroxyglutaric aciduria 2; carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and lung cancer (multiple). Orthologous to several human genes including IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (504591..505829)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The S. cerevisiae (Sc) Idp1, Idp2, and Idp3 are highly similar to Homo sapiens (Hs) Idh1 and Idh2 (67, 60 and 59% amino acid identity between Sc Idp1, Idp2, and Idp3, and Hs Idh1, respectively), and the arginine residues corresponding to R100 and R132 in Hs Idh1 (Hs Idh2 R140 and R172) are conserved in the corresponding yeast orthologs
Title: Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
there is an ancillary role for IDP1 in cellular glutamate synthesis and a role for IDP2 in equilibrating and maintaining cellular levels of isocitrate and alpha-ketoglutarate
Title: Kinetic properties and metabolic contributions of yeast mitochondrial and cytosolic NADP+-specific isocitrate dehydrogenases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxylate cycle	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in isocitrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: isocitrate dehydrogenase (NADP(+)) IDP2

NP_013275.1

EC 1.1.1.42

Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; mutation in human homolog IDH1 is associated with low-grade gliomas and secondary glioblastomas

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

504591..505829

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182061.1 → NP_013275.1 TPA: isocitrate dehydrogenase (NADP(+)) IDP2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013275.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYH8, P41939

UniProtKB/TrEMBL

A0A6L0ZPW5, A7A165, B3RH67, B5VN92, C7GIW4, C8ZDE7, G2WJ07, N1NZD0

Conserved Domains (1) summary

TIGR00127
Location:2 → 409

nadp_idh_euk; isocitrate dehydrogenase, NADP-dependent, eukaryotic type