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NMT1 glycylpeptide N-tetradecanoyltransferase NMT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850892, updated on 5-May-2024

Summary

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Gene symbol
NMT1
Gene description
glycylpeptide N-tetradecanoyltransferase NMT1
Primary source
SGD:S000004185
Locus tag
YLR195C
See related
AllianceGenome:SGD:S000004185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC72
Summary
Enables glycylpeptide N-tetradecanoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation. Located in cytosol. Orthologous to several human genes including NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (541937..543304, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ups1p Neighboring gene Ncw2p Neighboring gene rRNA-processing protein PWP1 Neighboring gene snoRNP complex protein NOP56

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli. De Cotiis DA, et al. Protein Expr Purif, 2008 Oct. PMID 18634883, Free PMC Article
  2. Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. Wu J, et al. J Biol Chem, 2007 Jul 27. PMID 17513302
  3. Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote. Boisson B, et al. J Biol Chem, 2003 Oct 31. PMID 12912986
  4. Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis. Farazi TA, et al. Biochemistry, 2001 Aug 7. PMID 11478885
  5. Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis. Farazi TA, et al. Biochemistry, 2001 May 29. PMID 11371195

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three crystal structures of Saccharomyces cerevisiae NMT: in binary complex with myristoyl-CoA (MYA) alone and in two ternary complexes.
    Title: Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-terminal peptidyl-glycine N-myristoylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glycylpeptide N-tetradecanoyltransferase NMT1
NP_013296.1
  • N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    541937..543304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182082.1 → NP_013296.1  TPA: glycylpeptide N-tetradecanoyltransferase NMT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013296.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYJ8, P14743
    UniProtKB/TrEMBL
    A0A8H4BY74, B5VNB5, C7GIS7, N1P6S8
    Conserved Domains (1) summary
    COG5092
    Location:1 → 455
    NMT1; N-myristoyl transferase [Lipid metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14743.1

Gene LinkOut

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