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BNA5 kynureninase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850933, updated on 4-Feb-2024

Summary

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Gene symbol
BNA5
Gene description
kynureninase
Primary source
SGD:S000004221
Locus tag
YLR231C
See related
AllianceGenome:SGD:S000004221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables kynureninase activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (605758..607119, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rho family GTPase CDC42 Neighboring gene tRNA-Ile Neighboring gene Est1p Neighboring gene DNA topoisomerase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Independent regulation of age associated fat accumulation and longevity. Beas AO, et al. Nat Commun, 2020 Jun 3. PMID 32493904, Free PMC Article
  2. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. Panozzo C, et al. FEBS Lett, 2002 Apr 24. PMID 12062417
  3. NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Bedalov A, et al. Mol Cell Biol, 2003 Oct. PMID 12972620, Free PMC Article
  4. A quantitative screen for metabolic enzyme structures reveals patterns of assembly across the yeast metabolic network. Noree C, et al. Mol Biol Cell, 2019 Oct 1. PMID 31483745, Free PMC Article
  5. Tryptophan plays an important role in yeast's tolerance to isobutanol. Liu HL, et al. Biotechnol Biofuels, 2021 Oct 13. PMID 34645498, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-hydroxykynureninase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynureninase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynureninase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynureninase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' NAD biosynthetic process from tryptophan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anthranilate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kynureninase
NP_013332.1
  • Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    605758..607119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182118.1 → NP_013332.1  TPA: kynureninase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013332.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYN2, Q05979
    UniProtKB/TrEMBL
    A0A6A5PUU6, A7A1B7, B3RHB9, B5VNE7, C7GR02, C8ZDJ5, G2WJ59, N1NYF6
    Conserved Domains (1) summary
    TIGR01814
    Location:4 → 451
    kynureninase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05979.1

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