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THI7 thiamine transporter THI7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850938, updated on 23-Nov-2023

Summary

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Gene symbol
THI7
Gene description
thiamine transporter THI7
Primary source
SGD:S000004227
Locus tag
YLR237W
See related
AllianceGenome:SGD:S000004227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
THI10
Summary
Enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity and thiamine transmembrane transporter activity. Involved in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport and thiamine transport. Located in plasma membrane. Used to study megaloblastic anemia. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (612367..614163)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase 3 Neighboring gene uncharacterized protein Neighboring gene Far10p Neighboring gene lipoyl(octanoyl) transferase LIP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defective high-affinity thiamine transporter leads to cell death in thiamine-responsive megaloblastic anemia syndrome fibroblasts. Stagg AR, et al. J Clin Invest, 1999 Mar. PMID 10074490, Free PMC Article
  2. Thiamine increases the resistance of baker's yeast Saccharomyces cerevisiae against oxidative, osmotic and thermal stress, through mechanisms partly independent of thiamine diphosphate-bound enzymes. Wolak N, et al. FEMS Yeast Res, 2014 Dec. PMID 25331172
  3. Identification and characterization of the thiamine transporter gene of Saccharomyces cerevisiae. Singleton CK. Gene, 1997 Oct 15. PMID 9358046
  4. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. Enjo F, et al. J Biol Chem, 1997 Aug 1. PMID 9235906
  5. Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster. Futagami T, et al. Yeast, 2017 Oct. PMID 28703391

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters, Thi7, Nrt1, and Thi72.
    Title: Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
  2. In this study,the authors performed the first phylogenetic classification of shochu strains using the nucleotide sequences of genes that reflect genome-level phylogeny. The single-nucleotide polymorphisms information identified in the present study is expected to be useful for distinguishing shochu yeast strains as part of quality control at shochu breweries.
    Title: Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables nucleobase transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables thiamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleobase transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in thiamine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thiamine transporter THI7
NP_013338.1
  • Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    612367..614163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182124.1 → NP_013338.1  TPA: thiamine transporter THI7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013338.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYN5, P87335, Q05998
    UniProtKB/TrEMBL
    A0A8H4BZP2, A7A1C0, B3RHC2, C7GQZ9, C8ZDK0, N1P1D9
    Conserved Domains (1) summary
    cd11482
    Location:27 → 505
    SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05998.1

Gene LinkOut

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