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FKS1 1,3-beta-D-glucan synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851055, updated on 17-May-2024

Summary

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Gene symbol
FKS1
Gene description
1,3-beta-D-glucan synthase
Primary source
FungiDB:YLR342W
Locus tag
YLR342W
See related
SGD:S000004334; AllianceGenome:SGD:S000004334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CND1; CWH53; ETG1; GSC1; PBR1
Summary
Enables 1,3-beta-D-glucan synthase activity. Involved in (1->3)-beta-D-glucan biosynthetic process; positive regulation of endocytosis; and regulation of cell size. Located in several cellular components, including actin cortical patch; cellular bud neck; and cellular bud tip. Part of 1,3-beta-D-glucan synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (809997..815627)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal protein P0 Neighboring gene Spo77p Neighboring gene uncharacterized protein Neighboring gene 1,3-beta-glucanosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1. Hu X, et al. Nature, 2023 Apr. PMID 36949198, Free PMC Article
  2. Novel Cell Wall Antifungals Reveal a Special Synergistic Activity in pbr1 Mutants Resistant to the Glucan Synthesis Antifungals Papulacandins and Echinocandins. Berzaghi R, et al. Front Microbiol, 2019. PMID 31428061, Free PMC Article
  3. RNA-Seq analysis of global transcriptomic changes suggests a roles for the MAPK pathway and carbon metabolism in cell wall maintenance in a Saccharomyces cerevisiae FKS1 mutant. Huang C, et al. Biochem Biophys Res Commun, 2018 Jun 7. PMID 29665361
  4. Absence of fks1p in lager brewing yeast results in aberrant cell wall composition and improved beer flavor stability. Wang JJ, et al. World J Microbiol Biotechnol, 2014 Jun. PMID 24488336
  5. Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data. Okada H, et al. Mol Biol Cell, 2014 Jan. PMID 24258022, Free PMC Article

See all (206) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and mechanistic insights into fungal beta-1,3-glucan synthase FKS1.
    Title: Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1.
  2. the mitotic spindle breakage observed in endocytosis mutants can be rescued either by deleting or inhibiting the activities of, CHS2, CHS3 and FKS1, which are involved in septum formation. The findings from our study highlight the importance of timely endocytosis of cytokinetic enzymes at the division site in safeguarding mitotic spindle integrity during mitotic exit.
    Title: Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit.
  3. Both the N terminus and the C terminus are essential for Fks1 function.
    Title: Topological and mutational analysis of Saccharomyces cerevisiae Fks1.
  4. Fks1p consists of multiple domains that are required for cell wall construction and cellular morphogenesis.
    Title: Multiple functional domains of the yeast l,3-beta-glucan synthase subunit Fks1p revealed by quantitative phenotypic analysis of temperature-sensitive mutants.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1,3-beta-D-glucan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1,3-beta-D-glucan synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1,3-beta-D-glucan synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1,3-beta-D-glucan synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in (1->3)-beta-D-glucan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in (1->3)-beta-D-glucan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of 1,3-beta-D-glucan synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of 1,3-beta-D-glucan synthase complex IEA
Inferred from Electronic Annotation
more info
  
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery HDA PubMed 
located_in cellular bud HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1,3-beta-D-glucan synthase
NP_013446.1
  • Catalytic subunit of 1,3-beta-D-glucan synthase; transfers glucose from UDP-glucose to growing chains of glucan via beta-1,3-glycosidic linkages, translocating polymerized beta-1,3-glucan to the extracellular space; role in cell wall synthesis and maintenance; functionally redundant with alternate catalytic subunit Gsc2p; activity regulated by Rho1p, a subunit of the synthase complex; localizes to sites of cell wall remodeling; contains a cellulose-synthase-like fold; antifungal drug target

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    809997..815627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182231.1 → NP_013446.1  TPA: 1,3-beta-D-glucan synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013446.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYY0, P38631, Q53YZ4, Q6TKS9, Q6TKT0
    UniProtKB/TrEMBL
    G2WJG0, N1P018
    Conserved Domains (3) summary
    pfam02364
    Location:808 → 1631
    Glucan_synthase; 1,3-beta-glucan synthase component
    pfam12273
    Location:18 → 80
    RCR; Chitin synthesis regulation, resistance to Congo red
    pfam14288
    Location:300 → 409
    FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38631.2

Gene LinkOut

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