PSA1 mannose-1-phosphate guanylyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PSA1
Gene description: mannose-1-phosphate guanylyltransferase
Primary source: SGD:S000002213
Locus tag: YDL055C
See related: AllianceGenome:SGD:S000002213
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MPG1; SRB1; VIG9
Summary: Enables mannose-1-phosphate guanylyltransferase activity. Involved in GDP-mannose biosynthetic process; cell wall mannoprotein biosynthetic process; and protein glycosylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2T; congenital muscular dystrophy-dystroglycanopathy A14; and muscular dystrophy-dystroglycanopathy. Orthologous to human GMPPB (GDP-mannose pyrophosphorylase B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (355674..356759, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of the MPG1 gene increased the level of GDP-mannose.
Title: Protein glycosylation in pmt mutants of Saccharomyces cerevisiae. Influence of heterologously expressed cellobiohydrolase II of Trichoderma reesei and elevated levels of GDP-mannose and cis-prenyltransferase activity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables mannose-1-phosphate guanylyltransferase (GTP) activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannose-1-phosphate guanylyltransferase (GTP) activity	IDA Inferred from Direct Assay more info	PubMed
enables mannose-1-phosphate guanylyltransferase (GTP) activity	IEA Inferred from Electronic Annotation more info
enables mannose-1-phosphate guanylyltransferase (GTP) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GDP-mannose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GDP-mannose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell wall mannoprotein biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular nitrogen compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannose-1-phosphate guanylyltransferase

NP_010228.1

EC 2.7.7.13

GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

355674..356759 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180114.1 → NP_010228.1 TPA: mannose-1-phosphate guanylyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010228.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRU1, P41940

UniProtKB/TrEMBL

A0A6A5Q114, A6ZXS0, B3LGV3, B5VFL2, C7GT83, C8Z4L4, G2WCA5, N1P486

Conserved Domains (2) summary

cd06425
Location:1 → 234

M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins

cl00160
Location:256 → 335

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...