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KGD2 dihydrolipoyl transsuccinylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851726, updated on 4-Jan-2025

Summary

Official Symbol
KGD2
Official Full Name
dihydrolipoyl transsuccinylase
Primary source
SGD:S000002555
Locus tag
YDR148C
See related
AllianceGenome:SGD:S000002555; FungiDB:YDR148C; VEuPathDB:YDR148C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dihydrolipoyllysine-residue succinyltransferase activity. Involved in 2-oxoglutarate metabolic process and cellular respiration. Located in mitochondrial nucleoid. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See KGD2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (753675..755066, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-binding transcription factor SWI5 Neighboring gene bifunctional choline kinase/ethanolamine kinase EKI1 Neighboring gene Num1p Neighboring gene putative mRNA-binding protein CTH1

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in mitochondrial nucleoid PubMed 
is_active_in mitochondrion PubMed 
located_in mitochondrion PubMed 
is_active_in mitochondrion  
located_in mitochondrion  
part_of oxoglutarate dehydrogenase complex PubMed 
part_of oxoglutarate dehydrogenase complex  

General protein information

Preferred Names
dihydrolipoyl transsuccinylase
NP_010432.3
  • Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    753675..755066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180455.3NP_010432.3  TPA: dihydrolipoyl transsuccinylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010432.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSD1, P19262
    UniProtKB/TrEMBL
    B3LGD2, C7GIQ3, C8Z564, G2WAP8, N1P4T9
    Conserved Domains (1) summary
    TIGR01347
    Location:74463
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
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