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LYS4 homoaconitate hydratase LYS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851820, updated on 13-Apr-2024

Summary

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Gene symbol
LYS4
Gene description
homoaconitate hydratase LYS4
Primary source
SGD:S000002642
Locus tag
YDR234W
See related
AllianceGenome:SGD:S000002642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LYS3
Summary
Predicted to enable homoaconitate hydratase activity. Involved in lysine biosynthetic process via aminoadipic acid. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (931129..933210)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 5-aminolevulinate synthase Neighboring gene Rtn1p Neighboring gene mRNA splicing protein PRP42 Neighboring gene riboflavin kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A unique fungal lysine biosynthesis enzyme shares a common ancestor with tricarboxylic acid cycle and leucine biosynthetic enzymes found in diverse organisms. Irvin SD, et al. J Mol Evol, 1998 Apr. PMID 9541534
  2. The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine biosynthesis pathway. Weidner G, et al. Mol Gen Genet, 1997 Jul. PMID 9268014
  3. Homoaconitic acid accumulation by a lysine-requiring yeast mutant. Maragoudakis ME. J Bacteriol, 1967 Oct. PMID 6051343, Free PMC Article
  4. Homocitric acid accumulation by a lysine-requiring yeast mutant. Maragoudakis ME, et al. J Biol Chem, 1966 Feb 10. PMID 5908136
  5. Cloning and physical characterization of linked lysine genes (lys4, lys15) of Saccharomyces cerevisiae. Wang L, et al. Curr Genet, 1989 Jul. PMID 2507177

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables homoaconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables homoaconitate hydratase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homoaconitate hydratase LYS4
NP_010520.3
  • Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    931129..933210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180542.3 → NP_010520.3  TPA: homoaconitate hydratase LYS4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010520.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSL5, P49367, Q66RF2, Q7LH77
    UniProtKB/TrEMBL
    A0A8H8UND9, B3LG54, C7GVB9, N1PAG0
    Conserved Domains (1) summary
    TIGR00139
    Location:20 → 693
    h_aconitase; homoaconitase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49367.1

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