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MSW1 tryptophan--tRNA ligase MSW1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851861, updated on 11-Apr-2024

Summary

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Gene symbol
MSW1
Gene description
tryptophan--tRNA ligase MSW1
Primary source
SGD:S000002676
Locus tag
YDR268W
See related
AllianceGenome:SGD:S000002676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tryptophan-tRNA ligase activity. Involved in mitochondrial tryptophanyl-tRNA aminoacylation. Located in mitochondrion. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1004004..1005143)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase HEL2 Neighboring gene iron-sulfur cluster assembly protein CIA1 Neighboring gene Cu(2+)-transporting P-type ATPase CCC2 Neighboring gene hydroxyacylglutathione hydrolase GLO2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MSW, a yeast gene coding for mitochondrial tryptophanyl-tRNA synthetase. Myers AM, et al. J Biol Chem, 1985 Dec 5. PMID 2999114
  2. An yeast nuclear mutation conferring temperature-sensitivity to the mitochondrial tryptophanyl-tRNA synthetase. Entrup R, et al. Curr Genet, 1992 Apr. PMID 1525855
  3. Mutations in the mitochondrial tryptophanyl-tRNA synthetase cause growth retardation and progressive leukoencephalopathy. Maffezzini C, et al. Mol Genet Genomic Med, 2019 Jun. PMID 30920170, Free PMC Article
  4. Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. Managbanag JR, et al. PLoS One, 2008. PMID 19030232, Free PMC Article
  5. Mitochondrial protein synthesis is required for maintenance of intact mitochondrial genomes in Saccharomyces cerevisiae. Myers AM, et al. EMBO J, 1985 Aug. PMID 3905388, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tryptophan-tRNA ligase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tryptophanyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tryptophan--tRNA ligase MSW1
NP_010554.1
  • Mitochondrial tryptophanyl-tRNA synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1004004..1005143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180576.1 → NP_010554.1  TPA: tryptophan--tRNA ligase MSW1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010554.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSQ2, P04803
    UniProtKB/TrEMBL
    A0A8H8UNH2, A6ZYM1, B3LG22, B5VGF2, C7GS89, C8Z5I1, G2WB11, N1PAG7
    Conserved Domains (1) summary
    TIGR00233
    Location:33 → 379
    trpS; tryptophanyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04803.2

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