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GLO2 hydroxyacylglutathione hydrolase GLO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851865, updated on 13-Apr-2024

Summary

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Gene symbol
GLO2
Gene description
hydroxyacylglutathione hydrolase GLO2
Primary source
SGD:S000002680
Locus tag
YDR272W
See related
AllianceGenome:SGD:S000002680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hydroxyacylglutathione hydrolase activity. Involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in cytoplasm. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1009010..1009834)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tryptophan--tRNA ligase MSW1 Neighboring gene Cu(2+)-transporting P-type ATPase CCC2 Neighboring gene Don1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glyoxalase II in Saccharomyces cerevisiae: in situ kinetics using the 5,5'-dithiobis(2-nitrobenzoic acid) assay. Martins AM, et al. Arch Biochem Biophys, 1999 Jun 1. PMID 10334858
  2. In situ kinetic analysis of glyoxalase I and glyoxalase II in Saccharomyces cerevisiae. Martins AM, et al. Eur J Biochem, 2001 Jul. PMID 11453985
  3. Heterologous expression, purification, and kinetic comparison of the cytoplasmic and mitochondrial glyoxalase II enzymes, Glo2p and Glo4p, from Saccharomyces cerevisiae. Bito A, et al. Protein Expr Purif, 1999 Dec. PMID 10600466
  4. Yeasts as Complementary Model Systems for the Study of the Pathological Repercussions of Enhanced Synphilin-1 Glycation and Oxidation. Seynnaeve D, et al. Int J Mol Sci, 2021 Feb 7. PMID 33562355, Free PMC Article
  5. Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins. Bito A, et al. J Biol Chem, 1997 Aug 22. PMID 9261170

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxyacylglutathione hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxyacylglutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydroxyacylglutathione hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydroxyacylglutathione hydrolase GLO2
NP_010558.3
  • Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1009010..1009834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180580.3 → NP_010558.3  TPA: hydroxyacylglutathione hydrolase GLO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010558.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSQ4, E9P8T0, Q05584
    UniProtKB/TrEMBL
    A0A8H8UNH4, A6ZYM3, B3LG20, B5VGF4, C7GS91, C8Z5I5, G2WB13, N1P8I8
    Conserved Domains (2) summary
    cd07723
    Location:16 → 188
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
    pfam16123
    Location:189 → 273
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05584.1

Gene LinkOut

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