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YDR341C arginine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851942, updated on 5-May-2024

Summary

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Gene symbol
YDR341C
Gene description
arginine--tRNA ligase
Primary source
SGD:S000002749
Locus tag
YDR341C
See related
AllianceGenome:SGD:S000002749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RRS1
Summary
Enables arginine-tRNA ligase activity. Involved in arginyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1151803..1153626, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene rRNA-processing protein FCF1 Neighboring gene tRNA-Ser Neighboring gene hexose transporter HXT7 Neighboring gene hexose transporter HXT6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Limited set of amino acid residues in a class Ia aminoacyl-tRNA synthetase is crucial for tRNA binding. Geslain R, et al. Biochemistry, 2003 Dec 30. PMID 14690419
  2. In vivo selection of lethal mutations reveals two functional domains in arginyl-tRNA synthetase. Geslain R, et al. RNA, 2000 Mar. PMID 10744027, Free PMC Article
  3. Crystallization and preliminary X-ray crystallographic analysis of yeast arginyl-tRNA synthetase-yeast tRNAArg complexes. Delagoutte B, et al. Acta Crystallogr D Biol Crystallogr, 2000 Apr. PMID 10739930
  4. A single base substitution in the variable pocket of yeast tRNA(Arg) eliminates species-specific aminoacylation. Liu W, et al. Biochim Biophys Acta, 1999 Dec 27. PMID 10594373
  5. L-arginine recognition by yeast arginyl-tRNA synthetase. Cavarelli J, et al. EMBO J, 1998 Sep 15. PMID 9736621, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arginine--tRNA ligase
NP_010628.3
  • Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1151803..1153626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180649.3 → NP_010628.3  TPA: arginine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010628.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSX2, Q05506
    UniProtKB/TrEMBL
    A0A8H8UNN9, A6ZYU2, C7GVV2, N1P779
    Conserved Domains (1) summary
    TIGR00456
    Location:31 → 607
    argS; arginyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05506.1

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