TRR1 thioredoxin-disulfide reductase TRR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TRR1
Gene description: thioredoxin-disulfide reductase TRR1
Primary source: FungiDB:YDR353W
Locus tag: YDR353W
See related: SGD:S000002761; AllianceGenome:SGD:S000002761
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ferrous iron binding activity and thioredoxin-disulfide reductase activity. Involved in cell redox homeostasis and cellular response to oxidative stress. Located in cytosol and mitochondrial intermembrane space. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TRR1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1183299..1184258)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endoplasmic reticulum stress-induced reactive oxygen species are detrimental for the fitness of a thioredoxin reductase mutant.
Title: Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant.
In searching for spontaneous suppressors of synthetic lethality of tsa1Delta rad51Delta double mutants, we identified that the loss of thioredoxin reductase Trr1 rescues their viability.
Title: Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants.
The cytosolic thioredoxin-thioredoxin reductase system and not the glutaredoxins contributes to the reduction of GSSG
Title: The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae.
Results suggest that redox control via the thioredoxin-thioredoxin reductase 1/2 system plays an important role in the regulation of translation.
Title: Activation of translation via reduction by thioredoxin-thioredoxin reductase in Saccharomyces cerevisiae.
the crystal structure of Trr1 at the resolution of 2.8 A, the first fungal TrxR structure
Title: Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin.
The iron-binding activity of thioredoxin reductase was identified.
Title: A novel role for thioredoxin reductase in the iron metabolism of S. cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ferrous iron binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin-disulfide reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin-disulfide reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables thioredoxin-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell redox homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin-disulfide reductase TRR1

NP_010640.1

EC 1.8.1.9

Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication