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APT2 adenine phosphoribosyltransferase APT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852051, updated on 13-Apr-2024

Summary

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Gene symbol
APT2
Gene description
adenine phosphoribosyltransferase APT2
Primary source
SGD:S000002849
Locus tag
YDR441C
See related
AllianceGenome:SGD:S000002849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable AMP binding activity; adenine binding activity; and adenine phosphoribosyltransferase activity. Predicted to be involved in AMP salvage and adenine salvage. Located in cytoplasm. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1344517..1345062, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Lrs4p Neighboring gene histone methyltransferase DOT1 Neighboring gene Ssn2p Neighboring gene putative hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase. Yuryev A, et al. Yeast, 1994 May. PMID 7941749
  2. APT1, but not APT2, codes for a functional adenine phosphoribosyltransferase in Saccharomyces cerevisiae. Alfonzo JD, et al. J Bacteriol, 1999 Jan. PMID 9864350, Free PMC Article
  3. Combining multisource information through functional-annotation-based weighting: gene function prediction in yeast. Ray SS, et al. IEEE Trans Biomed Eng, 2009 Feb. PMID 19272921
  4. Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues. Carlsson M, et al. PLoS One, 2018. PMID 29738539, Free PMC Article
  5. Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae. Saint-Marc C, et al. Curr Genet, 2020 Dec. PMID 32780163

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in AMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in AMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in adenine salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenine phosphoribosyltransferase APT2
NP_010729.3
  • Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1344517..1345062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180749.3 → NP_010729.3  TPA: adenine phosphoribosyltransferase APT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010729.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P36973, Q04090
    UniProtKB/TrEMBL
    A0A8H8UNX9, B3LFL8, B5VGX2, C7GTP4, G2WBH4, N1PAK2
    Conserved Domains (1) summary
    cl00309
    Location:11 → 180
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36973.2

Gene LinkOut

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