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TSA2 thioredoxin peroxidase TSA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852064, updated on 25-Apr-2024

Summary

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Gene symbol
TSA2
Gene description
thioredoxin peroxidase TSA2
Primary source
SGD:S000002861
Locus tag
YDR453C
See related
AllianceGenome:SGD:S000002861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables thioredoxin peroxidase activity. Involved in cell redox homeostasis; cellular response to oxidative stress; and protein folding. Located in cytoplasm. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to several human genes including PRDX1 (peroxiredoxin 1); PRDX2 (peroxiredoxin 2); and PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1365072..1365662, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Yhp1p Neighboring gene endopolyphosphatase Neighboring gene guanylate kinase Neighboring gene bifunctional K:H/Na:H antiporter NHX1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of TSA2 reveals novel features of the active-site loop of peroxiredoxins. Nielsen MH, et al. Acta Crystallogr D Struct Biol, 2016 Jan. PMID 26894543
  2. Site-specific mutagenesis of yeast 2-Cys peroxiredoxin improves heat or oxidative stress tolerance by enhancing its chaperone or peroxidase function. Hong SH, et al. Protoplasma, 2017 Jan. PMID 26843371
  3. Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms. Tairum CA, et al. Sci Rep, 2016 Sep 15. PMID 27629822, Free PMC Article
  4. Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: rate constants by competitive kinetics. Ogusucu R, et al. Free Radic Biol Med, 2007 Feb 1. PMID 17210445
  5. Cytosolic thioredoxin peroxidase I and II are important defenses of yeast against organic hydroperoxide insult: catalases and peroxiredoxins cooperate in the decomposition of H2O2 by yeast. Munhoz DC, et al. J Biol Chem, 2004 Aug 20. PMID 15210711

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel function for Tsa2p as a negative regulator of Aft1p-driven transcription, which is induced in V-ATPase mutants to limit transcription of the iron regulon.
    Title: Loss of vacuolar H+-ATPase (V-ATPase) activity in yeast generates an iron deprivation signal that is moderated by induction of the peroxiredoxin TSA2.
  2. show that the yeast Tsa1/Tsa2 peroxiredoxins colocalize to ribosomes and function to protect the Sup35 translation termination factor against oxidative stress-induced formation of its heritable [PSI(+)] prion conformation.
    Title: Ribosome-associated peroxiredoxins suppress oxidative stress-induced de novo formation of the [PSI+] prion in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin peroxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell redox homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thioredoxin peroxidase TSA2
NP_010741.1
  • Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress; TSA2 has a paralog, TSA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1365072..1365662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180761.1 → NP_010741.1  TPA: thioredoxin peroxidase TSA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010741.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT78, Q04120
    UniProtKB/TrEMBL
    A0A8H8UNY7, A6ZZ44, B5VGY3, C7GKP5, C8Z611, G2WBI4, N1P7J0
    Conserved Domains (1) summary
    cd03015
    Location:5 → 176
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04120.3

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