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APA2 bifunctional AP-4-A phosphorylase/ADP sulfurylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852143, updated on 17-May-2024

Summary

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Gene symbol
APA2
Gene description
bifunctional AP-4-A phosphorylase/ADP sulfurylase
Primary source
FungiDB:YDR530C
Locus tag
YDR530C
See related
SGD:S000002938; AllianceGenome:SGD:S000002938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables bis(5'-nucleosyl)-tetraphosphatase activity. Involved in nucleoside catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1496791..1497768, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hlr1p Neighboring gene ubiquinol--cytochrome-c reductase subunit 7 Neighboring gene pantothenate kinase Neighboring gene Kre28p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures of yeast Apa2 reveal catalytic insights into a canonical AP₄A phosphorylase of the histidine triad superfamily. Hou WT, et al. J Mol Biol, 2013 Aug 9. PMID 23628156
  2. Diadenosine 5',5'''-P1, P4-tetraphosphate alpha, beta-phosphorylase from yeast supports nucleoside diphosphate-phosphate exchange. Guranowski A, et al. J Biol Chem, 1986 May 5. PMID 3009435
  3. Isolation and characterisation of the linked genes APA2 and QCR7, coding for Ap4A phosphorylase II and the 14 kDa subunit VII of the mitochondrial bc1-complex in the yeast Kluyveromyces lactis. Mulder W, et al. Biochim Biophys Acta, 1994 Nov 22. PMID 7948033
  4. An alleged yeast polyphosphate kinase is actually diadenosine-5', 5"'-P1,P4-tetraphosphate alpha,beta-phosphorylase. Booth JW, et al. J Biol Chem, 1995 Aug 18. PMID 7642617
  5. Catabolism of bis(5'-nucleosidyl) tetraphosphates in Saccharomyces cerevisiae. Plateau P, et al. J Bacteriol, 1990 Dec. PMID 2174863, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP:ADP adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfate adenylyltransferase (ADP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate adenylyltransferase (ADP) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleoside catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional AP-4-A phosphorylase/ADP sulfurylase
NP_010819.1
  • Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1496791..1497768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180838.1 → NP_010819.1  TPA: bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010819.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTF1, P22108
    UniProtKB/TrEMBL
    A0A8H8UP59, A6ZZB7, B3LFE1, C8Z690
    Conserved Domains (1) summary
    COG4360
    Location:1 → 314
    APA2; ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22108.1

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