PRS4 ribose phosphate diphosphokinase subunit PRS4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: PRS4
Gene description: ribose phosphate diphosphokinase subunit PRS4
Primary source: SGD:S000000164
Locus tag: YBL068W
See related: AllianceGenome:SGD:S000000164
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process and fungal-type cell wall organization. Located in cytoplasm. Part of ribose phosphate diphosphokinase complex. Used to study diabetes insipidus and fundus dystrophy. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to several human genes including PRPS1 (phosphoribosyl pyrophosphate synthetase 1) and PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribose phosphate diphosphokinase activity	IEA Inferred from Electronic Annotation more info
contributes_to ribose phosphate diphosphokinase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of ribose phosphate diphosphokinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribose phosphate diphosphokinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribose phosphate diphosphokinase complex	IEA Inferred from Electronic Annotation more info

NP_009485.3

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic

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