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GAL7 UDP-glucose:hexose-1-phosphate uridylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852306, updated on 11-Apr-2024

Summary

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Gene symbol
GAL7
Gene description
UDP-glucose:hexose-1-phosphate uridylyltransferase
Primary source
SGD:S000000222
Locus tag
YBR018C
See related
AllianceGenome:SGD:S000000222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in galactose catabolic process via UDP-galactose. Located in cytoplasm. Used to study galactosemia. Human ortholog(s) of this gene implicated in classic galactosemia and galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (274427..275527, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP1 Neighboring gene Kap104p Neighboring gene ncRNA Neighboring gene bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase Neighboring gene galactokinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast. Sirr A, et al. Genetics, 2015 Jan. PMID 25398792, Free PMC Article
  2. Transcriptomic analysis of Saccharomyces cerevisiae physiology in the context of galactose assimilation perturbations. Syriopoulos C, et al. Mol Biosyst, 2008 Sep. PMID 18704232
  3. Subcellular localization of galactose-1-phosphate uridylyltransferase in the yeast Saccharomyces cerevisiae. Christacos NC, et al. Mol Genet Metab, 2000 Aug. PMID 10993714
  4. Functional consequence of substitutions at residue 171 in human galactose-1-phosphate uridylyltransferase. Crews C, et al. J Biol Chem, 2000 Jul 28. PMID 10811638
  5. Primary structure of the Saccharomyces cerevisiae GAL7 gene. Tajima M, et al. Yeast, 1985 Sep. PMID 2851900

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. quantitative relationship between galactokinase activity, gal-1P accumulation, and growth arrest of galactose-challenged GALT or GALE-deficiency
    Title: Distinct roles of galactose-1P in galactose-mediated growth arrest of yeast deficient in galactose-1P uridylyltransferase (GALT) and UDP-galactose 4'-epimerase (GALE).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose catabolic process via UDP-galactose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactose catabolic process via UDP-galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UDP-glucose:hexose-1-phosphate uridylyltransferase
NP_009574.1
  • Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human homolog UGP2 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    274427..275527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178366.1 → NP_009574.1  TPA: UDP-glucose:hexose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009574.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ20, P04398, P08431
    UniProtKB/TrEMBL
    A6ZKW4, B5VDY7, C7GM34, G2W925, N1P6E1
    Conserved Domains (1) summary
    TIGR00209
    Location:3 → 366
    galT_1; galactose-1-phosphate uridylyltransferase, family 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08431.4

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