U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GAL10 bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852307, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
GAL10
Gene description
bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase
Primary source
SGD:S000000223
Locus tag
YBR019C
See related
AllianceGenome:SGD:S000000223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables UDP-glucose 4-epimerase activity and aldose 1-epimerase activity. Involved in galactose catabolic process via UDP-galactose. Located in cytosol. Used to study galactosemia. Human ortholog(s) of this gene implicated in galactose epimerase deficiency and galactosemia. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (276253..278352, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Kap104p Neighboring gene UDP-glucose:hexose-1-phosphate uridylyltransferase Neighboring gene ncRNA Neighboring gene galactokinase Neighboring gene uracil permease

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p. Scott A, et al. FEMS Yeast Res, 2007 May. PMID 17253981
  2. Relationship between UDP-galactose 4'-epimerase activity and galactose sensitivity in yeast. Wasilenko J, et al. J Biol Chem, 2006 Mar 31. PMID 16452467
  3. The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae. Thoden JB, et al. J Biol Chem, 2005 Jun 10. PMID 15795221
  4. The Hypocrea jecorina gal10 (uridine 5'-diphosphate-glucose 4-epimerase-encoding) gene differs from yeast homologues in structure, genomic organization and expression. Seiboth B, et al. Gene, 2002 Jul 24. PMID 12242021
  5. The enzymes of the galactose cluster in Saccharomyces cerevisiae. II. Purification and characterization of uridine diphosphoglucose 4-epimerase. Fukasawa T, et al. J Biol Chem, 1980 Apr 10. PMID 6987227

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We suggest that GAL10-ncRNA tunes the expression of GAL genes by additional mechanisms besides suppressing leaky transcription from the GAL1-10 promoter.
    Title: A novel CRE recombinase assay for quantification of GAL10-non coding RNA suppression on transcriptional leakage.
  2. NuA4 Histone Acetyltransferase associates with the GAL10 antisense transcription initiation site at the 3' end of the coding sequence.
    Title: Regulation of Antisense Transcription by NuA4 Histone Acetyltransferase and Other Chromatin Regulatory Factors.
  3. RNA polymerase II is targeted to the antisense initiation site at GAL10 by Reb1p activator as well as general transcription factors (e.g., TFIID, TFIIB, and Mediator) for antisense transcription initiation.
    Title: Mechanisms of antisense transcription initiation from the 3' end of the GAL10 coding sequence in vivo.
  4. quantitative relationship between galactokinase activity, gal-1P accumulation, and growth arrest of galactose-challenged GALT or GALE-deficiency
    Title: Distinct roles of galactose-1P in galactose-mediated growth arrest of yeast deficient in galactose-1P uridylyltransferase (GALT) and UDP-galactose 4'-epimerase (GALE).
  5. molecular amalysis of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae
    Title: The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae.
  6. The epimerase and mutarotase activities do not appear to influence each other. Protein is a dimer in solution.
    Title: Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p.
  7. The 3-dimensional structure of the dual-function enzyme Gal10p was determined at 1.85-Angstrom resolution. It folds into 2 separate and distinct units (corresponding to the epimerase and mutarotase domains) that are connected by a simple Type II turn.
    Title: The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables UDP-glucose 4-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose 4-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-glucose 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 4-epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables aldose 1-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldose 1-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose catabolic process via UDP-galactose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactose catabolic process via UDP-galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase
NP_009575.1
  • UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; human homolog GALE implicated in galactosemia, can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    276253..278352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178367.1 → NP_009575.1  TPA: bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009575.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ21, P04397
    UniProtKB/TrEMBL
    A6ZKW5, B3LNC2, B5VDY8, C7GM33, C8Z413
    Conserved Domains (2) summary
    cd09019
    Location:376 → 698
    galactose_mutarotase_like; galactose mutarotase_like
    cd05247
    Location:14 → 349
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04397.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous