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PHO5 acid phosphatase PHO5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852390, updated on 4-Feb-2024

Summary

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Gene symbol
PHO5
Gene description
acid phosphatase PHO5
Primary source
SGD:S000000297
Locus tag
YBR093C
See related
AllianceGenome:SGD:S000000297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables acid phosphatase activity; nucleoside-triphosphatase activity; and nucleoside-triphosphate diphosphatase activity. Involved in cellular response to phosphate starvation and phosphate-containing compound metabolic process. Located in fungal-type cell wall. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia and thyroid gland papillary carcinoma. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (429548..430951, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tim12p Neighboring gene acid phosphatase PHO3 Neighboring gene putative tubulin tyrosine ligase Neighboring gene Rxt2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleosomal promoter variation generates gene expression noise. Brown CR, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25468975, Free PMC Article
  2. The yeast PHO5 promoter: from single locus to systems biology of a paradigm for gene regulation through chromatin. Korber P, et al. Nucleic Acids Res, 2014. PMID 25190457, Free PMC Article
  3. Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity. Small EC, et al. Proc Natl Acad Sci U S A, 2014 Jun 17. PMID 24889621, Free PMC Article
  4. Quantitative analysis of the transcription control mechanism. Mao C, et al. Mol Syst Biol, 2010 Nov 19. PMID 21081924, Free PMC Article
  5. MethylViewer: computational analysis and editing for bisulfite sequencing and methyltransferase accessibility protocol for individual templates (MAPit) projects. Pardo CE, et al. Nucleic Acids Res, 2011 Jan. PMID 20959287, Free PMC Article

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A review of the PHO5 promoter as a paradigm for gene regulation through chromatin remodeling.
    Title: The yeast PHO5 promoter: from single locus to systems biology of a paradigm for gene regulation through chromatin.
  2. three histone methylation mutants exhibited more severe growth defects and slower activation of GAL1, SSA3 and PHO5 than those of wild type
    Title: [Effects of histone H3 K4L and K36L mutations on the cell growth and the transcription of GAL1, SSA3 and PHO5 in Saccharomyces cerevisiae].
  3. The results show that remodels the structure of chromatin (RSC) is crucially involved in PHO5 promoter opening.
    Title: The RSC chromatin remodeling complex has a crucial role in the complete remodeler set for yeast PHO5 promoter opening.
  4. we provide evidence that topoisomerases are required to maintain the PHO5 promoter in a superhelical state, which is competent for proper activation.
    Title: DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.
  5. data suggest that Set1-mediated H3K4me suppresses nucleosome remodeling at the PHO5 promoter so as to reduce basal transcription of PHO5 under repressive conditions
    Title: Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter.
  6. auxiliary role for DNA binding competition between Pho4 and histones in PHO5 promoter chromatin remodeling
    Title: In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.
  7. The Mcm1-Fkh2 complex, first shown to transactivate genes within the CLB2 cluster that drive G(2)/M progression, also associated directly at the PHO5 promoter in a cell cycle-dependent manner.
    Title: Coupling phosphate homeostasis to cell cycle-specific transcription: mitotic activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead proteins.
  8. Nap1 regulates transcription of PHO5.
    Title: Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.
  9. analysis of complete independence of promoter chromatin opening from downstream PHO5 transcription processes
    Title: Redundancy of chromatin remodeling pathways for the induction of the yeast PHO5 promoter in vivo.
  10. Chromatin diassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.
    Title: Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acid phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside triphosphate diphosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables nucleoside triphosphate diphosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to phosphate starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphate-containing compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size HMP PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acid phosphatase PHO5
NP_009651.3
  • Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    429548..430951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178441.3 → NP_009651.3  TPA: acid phosphatase PHO5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009651.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ94, P00635
    UniProtKB/TrEMBL
    A0A8H4F6L0, A6ZL40, B3LN58, D3UEI8
    Conserved Domains (1) summary
    pfam00328
    Location:65 → 399
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00635.2

Gene LinkOut

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