ARA1 D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ARA1
Gene description: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1
Primary source: SGD:S000000353
Locus tag: YBR149W
See related: AllianceGenome:SGD:S000000353
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables D-arabinose 1-dehydrogenase [NAD(P)+] activity. Involved in cellular carbohydrate metabolic process. Located in cytosol. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (539987..541021)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A structural study of Ara1 revealed that induced fit upon NADPH binding yielded an intact active-site pocket that recognizes the substrate.
Title: Structures of Saccharomyces cerevisiae D-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition.
Characterizeion of Ara1 as an oxidoreductase that can reduce racemic acetoin to meso-2,3-butanediol and (2S,3S)-2,3-butanediol in the presence of NADPH.
Title: Role of Saccharomyces cerevisiae oxidoreductases Bdh1p and Ara1p in the metabolism of acetoin and 2,3-butanediol.
It demonstrates that Ara2p, not Ara1p, mainly contributes to the production of Erythroascorbic acid from d-arabinose in S. cerevisiae.
Title: NAD+-specific D-arabinose dehydrogenase and its contribution to erythroascorbic acid production in Saccharomyces cerevisiae.
Ara1p catalyzed the reduction of the reactive alpha,beta-dicarbonyl compounds methylglyoxal, diacetyl, and pentanedione in a NADPH dependant manner.
Title: Alpha,beta-dicarbonyl reduction by Saccharomyces D-arabinose dehydrogenase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables D-arabinose 1-dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables D-arabinose 1-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables D-arabinose 1-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables D-arabinose 1-dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables diacetyl reductase ((S)-acetoin forming) activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetoin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1

NP_009707.3

EC 1.1.1.117

NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

539987..541021

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178497.3 → NP_009707.3 TPA: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009707.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQE4, P38115

UniProtKB/TrEMBL

A0A6A5Q1Y8, A6ZL91, B3LN10, C7GY29, D3UEP3, N1PAT8

Conserved Domains (1) summary

cd19119
Location:22 → 321

AKR_AKR3C1; Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins