Cnga1 cyclic nucleotide gated channel subunit alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnga1provided by RGD
Official Full Name: cyclic nucleotide gated channel subunit alpha 1provided by RGD
Primary source: RGD:621815
See related: Ensembl:ENSRNOG00000004778 AllianceGenome:RGD:621815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HCN; Cncg
Summary: Enables cGMP binding activity and intracellular cGMP-activated cation channel activity. Involved in membrane depolarization; regulation of cytosolic calcium ion concentration; and spermatogenesis. Located in cytoplasm and terminal bouton. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 15.9), Thymus (RPKM 3.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (35920948..35959065)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (35566947..35605065)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (38155771..38171107)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
Title: Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
Histamine depolarizes projection neurons but not interneurons in the cerebellar nuclei via the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels coupled to histamine H2 receptors.
Title: Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels.
Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.
Title: Insulin receptor regulates photoreceptor CNG channel activity.
estrogen and progesterone act in renal tissues modulating CNG-A1 and Na/K ATPase gene expression
Title: Role of estrogen and progesterone in the modulation of CNG-A1 and Na/K+-ATPase expression in the renal cortex.
Data demonstrate that CNGA1 is expressed in rat cerebellar granule cells and forms functional channels.
Title: Functional cGMP-gated channels in cerebellar granule cells.
Data show robust CNGA1 (but not CNGA2 or CNGA3) channel expression principally in rat alveolar type I cells and suggest that CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.
Title: Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.
Grb14 is a normal physiological modulator of CNG channel function in vivo.
Title: Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.
suggest a potential role for HCN channels in regulation of glucagon secretion via modulating Ca(2+) and Na(+) channel activities
Title: Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells.
Our data imply that HCN-expressing GABAergic neurons provide rhythmic drive in all phases of the hippocampal theta activity.
Title: The presence of pacemaker HCN channels identifies theta rhythmic GABAergic neurons in the medial septum.
Cyclic nucleotide-gated channels (CNG1 and CNG2 A subunits) affect membrane potential and excitability of rat medial vestibular nucleus.
Title: Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135428 (e-PCR)
- UniSTS:218705

RH142314 (e-PCR)
- UniSTS:231561

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cAMP binding	ISS Inferred from Sequence or Structural Similarity more info
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cGMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cAMP-activated cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cGMP-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment membrane	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in rod photoreceptor outer segment	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cGMP-gated cation channel alpha-1

Names: CNG channel alpha-1; CNG-1; CNG1; cyclic nucleotide gated channel alpha 1; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated channel subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053497.2 → NP_445949.2 cGMP-gated cation channel alpha-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

O08659, Q62927

UniProtKB/TrEMBL

F1LQN0

Related

ENSRNOP00000006469.3, ENSRNOT00000006469.5

Conserved Domains (3) summary

cd00038
Location:470 → 586

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:156 → 398

Ion_trans; Ion transport protein

pfam16526
Location:586 → 655

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

35920948..35959065

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092516.2 → XP_038948444.1 cGMP-gated cation channel alpha-1 isoform X1

UniProtKB/Swiss-Prot

O08659, Q62927

UniProtKB/TrEMBL

F1LQN0

Conserved Domains (3) summary

cd00038
Location:470 → 586

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:156 → 398

Ion_trans; Ion transport protein

pfam16526
Location:586 → 655

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels