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Entpd6 ectonucleoside triphosphate diphosphohydrolase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85260, updated on 6-Jun-2024

Summary

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Official Symbol
Entpd6provided by RGD
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 6provided by RGD
Primary source
RGD:619725
See related
Ensembl:ENSRNOG00000007427 AllianceGenome:RGD:619725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables pyrophosphatase activity. Involved in response to calcium ion and response to magnesium ion. Located in several cellular components, including Golgi apparatus; cell surface; and extracellular space. Orthologous to human ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 106.9), Heart (RPKM 63.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Entpd6 in Genome Data Viewer
Location:
3q41
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160036055..160058580)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139575659..139598163)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146546424..146568828)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350499 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486465 Neighboring gene glycogen phosphorylase B Neighboring gene abhydrolase domain containing 12, lysophospholipase Neighboring gene uncharacterized LOC134486181

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction. O'Keeffe MG, et al. J Vestib Res, 2012. PMID 23302703
  2. Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function. Ivanenkov VV, et al. Biochemistry, 2003 Oct 14. PMID 14529283
  3. Sequencing, functional expression and characterization of rat NTPDase6, a nucleoside diphosphatase and novel member of the ecto-nucleoside triphosphate diphosphohydrolase family. Braun N, et al. Biochem J, 2000 Nov 1. PMID 11042118, Free PMC Article
  4. Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2). Hicks-Berger CA, et al. J Biol Chem, 2000 Nov 3. PMID 10948193
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NTPDase6 immunolocalisation in the vestibular end organ could be linked to the regulation of P2 receptor signalling and sensory transduction, including maintenance of vestibular hair bundles.
    Title: Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables IDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables IDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to magnesium ion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 6
Names
CD39 antigen-like 2
NTPDase 6
NP_445950.1
XP_006235280.1
XP_063140810.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429515.1 → NP_001416444.1  ectonucleoside triphosphate diphosphohydrolase 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9ER31
    UniProtKB/TrEMBL
    A6KHG0

  2. NM_053498.1 → NP_445950.1  ectonucleoside triphosphate diphosphohydrolase 6

    See identical proteins and their annotated locations for NP_445950.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ277748
    UniProtKB/Swiss-Prot
    Q9ER31
    UniProtKB/TrEMBL
    A6KHG0
    Related
    ENSRNOP00000009946.3, ENSRNOT00000009946.6
    Conserved Domains (1) summary
    cl17037
    Location:71 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    160036055..160058580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284740.1 → XP_063140810.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

  2. XM_006235218.5 → XP_006235280.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

    Conserved Domains (1) summary
    cl17037
    Location:71 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_010064708.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER31.1 GenPept UniProtKB/Swiss-Prot:Q9ER31

Gene LinkOut

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