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LYS5 holo-[acyl-carrier-protein] synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852723, updated on 23-Nov-2023

Summary

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Gene symbol
LYS5
Gene description
holo-[acyl-carrier-protein] synthase
Primary source
SGD:S000003122
Locus tag
YGL154C
See related
AllianceGenome:SGD:S000003122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables holo-[acyl-carrier-protein] synthase activity. Involved in lysine biosynthetic process via aminoadipic acid. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (215278..216096, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene alpha-mannosidase Neighboring gene protein geranylgeranyltransferase type I subunit CDC43 Neighboring gene Pex14p Neighboring gene Nut1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Positive and negative selection LYS5MX gene replacement cassettes for use in Saccharomyces cerevisiae. Ito-Harashima S, et al. Yeast, 2004 Jan 15. PMID 14745782
  2. The LYS5 gene of Saccharomyces cerevisiae. Miller KG, et al. Gene, 1996 Jun 12. PMID 8654981
  3. Cloning and biochemical characterization of LYS5 gene of Saccharomyces cerevisiae. Borell CW, et al. Curr Genet, 1988 Apr. PMID 2839304
  4. Properties of revertants of lys2 and lys5 mutants as well as alpha-aminoadipate-semialdehyde dehydrogenase from Saccharomyces cerevisiae. Storts DR, et al. Biochem Biophys Res Commun, 1989 May 30. PMID 2499333
  5. Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene. Praphanphoj V, et al. Mol Genet Metab, 2001 Apr. PMID 11286508

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results structurally and functionally characterized the FAS type I PPT as part of the multienzyme protein and as an isolated domain.
    Title: Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables holo-[acyl-carrier-protein] synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables holo-[acyl-carrier-protein] synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables holo-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lysine biosynthetic process via aminoadipic acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysine biosynthetic process via aminoadipic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
holo-[acyl-carrier-protein] synthase
NP_011361.1
  • Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    215278..216096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181019.1 → NP_011361.1  TPA: holo-[acyl-carrier-protein] synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTZ7, P50113
    UniProtKB/TrEMBL
    A0A8H4C082, A6ZU31, B3LHK7, B5VIH5, C7GPQ2, C8Z897, G2WDV1, N1P2Y4
    Conserved Domains (1) summary
    COG2091
    Location:19 → 255
    Sfp; Phosphopantetheinyl transferase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50113.1

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