U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GSC2 1,3-beta-glucan synthase GSC2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852920, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
GSC2
Gene description
1,3-beta-glucan synthase GSC2
Primary source
FungiDB:YGR032W
Locus tag
YGR032W
See related
SGD:S000003264; AllianceGenome:SGD:S000003264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FKS2
Summary
Enables 1,3-beta-D-glucan synthase activity. Involved in (1->3)-beta-D-glucan biosynthetic process and ascospore wall assembly. Located in prospore membrane. Part of 1,3-beta-D-glucan synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (548264..553951)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribonuclease P/MRP protein subunit POP6 Neighboring gene Imo32p Neighboring gene Nag1p Neighboring gene Tim21p Neighboring gene ribosomal 60S subunit protein L26B

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase. Kondoh O, et al. Biol Pharm Bull, 2005 Nov. PMID 16272705
  2. Biosynthesis of the yeast cell wall. II. Regulation of beta-(1 leads to 3)glucan synthetase by ATP and GTP. Shematek EM, et al. J Biol Chem, 1980 Feb 10. PMID 6766140
  3. New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium species. Johnson ME, et al. Antimicrob Agents Chemother, 2011 Aug. PMID 21576441, Free PMC Article
  4. The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae. Huang LS, et al. Proc Natl Acad Sci U S A, 2005 Aug 30. PMID 16116083, Free PMC Article
  5. Differential sensitivity between Fks1p and Fks2p against a novel beta -1,3-glucan synthase inhibitor, aerothricin3 [corrected]. Kondoh O, et al. J Biol Chem, 2002 Nov 1. PMID 12202487

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ste11 regulates the FKS2 gene through its substrates and through Mpk1.
    Title: Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene.
  2. The dimeric complex of Mpk1 binds to a Swi4 recognition site in the FKS2 promoter.[Mpk1, Swi4, FKS2]
    Title: Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF.
  3. negative regulation of GSC2 by SMK1 is important for spore wall deposition
    Title: The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1,3-beta-D-glucan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1,3-beta-D-glucan synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1,3-beta-D-glucan synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in (1->3)-beta-D-glucan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in (1->3)-beta-D-glucan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore wall assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 1,3-beta-D-glucan synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of 1,3-beta-D-glucan synthase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cell periphery HDA PubMed 
located_in cellular bud neck HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
1,3-beta-glucan synthase GSC2
NP_011546.3
  • Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    548264..553951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181161.3 → NP_011546.3  TPA: 1,3-beta-glucan synthase GSC2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011546.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUG8, P40989, Q45U52
    UniProtKB/TrEMBL
    A0A8H4C270, G2WEC2, N1P5P7
    Conserved Domains (2) summary
    pfam02364
    Location:827 → 1650
    Glucan_synthase; 1,3-beta-glucan synthase component
    pfam14288
    Location:320 → 428
    FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40989.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous