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SKN1 beta-glucan synthesis-associated protein SKN1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853045, updated on 17-May-2024

Summary

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Gene symbol
SKN1
Gene description
beta-glucan synthesis-associated protein SKN1
Primary source
FungiDB:YGR143W
Locus tag
YGR143W
See related
SGD:S000003375; AllianceGenome:SGD:S000003375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glucosidase activity. Involved in several processes, including (1->6)-beta-D-glucan biosynthetic process; fungal-type cell wall organization; and negative regulation of autophagy. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SKN1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (775193..777508)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Btn2p Neighboring gene tRNA-Ala Neighboring gene tRNA-Gly Neighboring gene thiamine thiazole synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. Thevissen K, et al. FEMS Microbiol Lett, 2010 Feb. PMID 20030721, Free PMC Article
  2. Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast. Aerts AM, et al. FEBS Lett, 2006 Mar 20. PMID 16527275
  3. SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. Thevissen K, et al. FEBS Lett, 2005 Mar 28. PMID 15792805
  4. Localization of synthesis of beta1,6-glucan in Saccharomyces cerevisiae. Montijn RC, et al. J Bacteriol, 1999 Dec. PMID 10601196, Free PMC Article
  5. SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Roemer T, et al. Mol Cell Biol, 1993 Jul. PMID 8321211, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data point to a negative regulation of autophagy by both Ipt1 and Skn1 in yeast, with a putative involvement of phytosphingosine in this process.
    Title: Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae.
  2. SKN1 is involved in sphingolipid biosynthesis in S. cerevisiae.
    Title: SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in (1->6)-beta-D-glucan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in (1->6)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sphingolipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-glucan synthesis-associated protein SKN1
NP_011659.3
  • Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    775193..777508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181272.3 → NP_011659.3  TPA: beta-glucan synthesis-associated protein SKN1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011659.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUS3, P33336
    UniProtKB/TrEMBL
    A0A8H4C0Q9, B3LI87, C8Z936, N1P9X0
    Conserved Domains (1) summary
    pfam03935
    Location:249 → 763
    SKN1; Beta-glucan synthesis-associated protein (SKN1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33336.1

Gene LinkOut

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