CYS4 cystathionine beta-synthase CYS4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: CYS4
Gene description: cystathionine beta-synthase CYS4
Primary source: FungiDB:YGR155W
Locus tag: YGR155W
See related: SGD:S000003387; AllianceGenome:SGD:S000003387
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NHS5; STR4; VMA41
Summary: Enables cystathionine beta-synthase activity. Involved in cysteine metabolic process; hydrogen sulfide biosynthetic process; and traversing start control point of mitotic cell cycle. Located in cytoplasm. Used to study homocystinuria. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cystathionine beta-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine beta-synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cystathionine beta-synthase activity	IEA Inferred from Electronic Annotation more info
enables cystathionine beta-synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process from serine	IDA Inferred from Direct Assay more info	PubMed
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process via cystathionine	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process via cystathionine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cysteine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen sulfide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in serine family amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sulfur compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in transsulfuration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in traversing start control point of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed

NP_011671.3

Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant