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PSD2 phosphatidylserine decarboxylase 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853080, updated on 17-May-2024

Summary

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Gene symbol
PSD2
Gene description
phosphatidylserine decarboxylase 2
Primary source
FungiDB:YGR170W
Locus tag
YGR170W
See related
SGD:S000003402; AllianceGenome:SGD:S000003402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylserine decarboxylase activity. Involved in phosphatidylcholine biosynthetic process. Located in endosome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PSD2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (837142..840558)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS6 Neighboring gene Lso2p Neighboring gene methionine--tRNA ligase MSM1 Neighboring gene transporter YIP1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reconstitution of phosphatidylserine transport from chemically defined donor membranes to phosphatidylserine decarboxylase 2 implicates specific lipid domains in the process. Wu WI, et al. J Biol Chem, 2004 Feb 20. PMID 14660568
  2. The C2 domain of phosphatidylserine decarboxylase 2 is not required for catalysis but is essential for in vivo function. Kitamura H, et al. J Biol Chem, 2002 Sep 13. PMID 12093819
  3. Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells. Swagatika S, et al. FEBS Open Bio, 2022 May. PMID 33999504, Free PMC Article
  4. Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum. Raychaudhuri S, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18836080, Free PMC Article
  5. Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae. Bürgermeister M, et al. Biochim Biophys Acta, 2004 Nov 8. PMID 15522832

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase.
    Title: Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase.
  2. results showed that VID22 is required for transcriptional activation of the PSD2 gene.
    Title: VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae.
  3. model predicts that this process involves an acceptor membrane complex containing the C2 domains of Psd2p, PstB2p, and Pbi1p that ligate to Scs2p and phosphatidic acid present in the donor membrane
    Title: An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae.
  4. Data demonstrate that loss of Psd2 causes cells to acquire sensitivity to cadmium even though Psd1 remains intact.
    Title: Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance.
  5. mitochondrial biosynthesis of phosphatidylethanolamine is essential for the viability of yeast mutants lacking cardiolipin
    Title: Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine decarboxylase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycerophospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylserine decarboxylase 2
NP_011686.1
  • Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    837142..840558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181299.1 → NP_011686.1  TPA: phosphatidylserine decarboxylase 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011686.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUV4, P53037
    UniProtKB/TrEMBL
    A0A8H4C0K0, B3LI60, C7GQ77, N1P3V1
    Conserved Domains (3) summary
    cd00030
    Location:19 → 86
    C2; C2 domain
    PLN02964
    Location:523 → 1079
    PLN02964; phosphatidylserine decarboxylase
    NF033845
    Location:276 → 453
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53037.1

Gene LinkOut

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