U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MSM1 methionine--tRNA ligase MSM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853081, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
MSM1
Gene description
methionine--tRNA ligase MSM1
Primary source
SGD:S000003403
Locus tag
YGR171C
See related
AllianceGenome:SGD:S000003403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables methionine-tRNA ligase activity. Involved in methionyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (840824..842551, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Lso2p Neighboring gene phosphatidylserine decarboxylase 2 Neighboring gene transporter YIP1 Neighboring gene Rbg2p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of MSM1, the structural gene for yeast mitochondrial methionyl-tRNA synthetase. Tzagoloff A, et al. Eur J Biochem, 1989 Feb 1. PMID 2645139
  2. Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions. Senger B, et al. J Mol Biol, 2001 Aug 3. PMID 11469869
  3. Purification of the yeast mitochondrial methionyl-tRNA synthetase. Common and distinctive features of the cytoplasmic and mitochondrial isoenzymes. Schwob E, et al. Eur J Biochem, 1988 Dec 1. PMID 3060359
  4. Incorporation of the Arc1p tRNA-binding domain to the catalytic core of MetRS can functionally replace the yeast Arc1p-MetRS complex. Karanasios E, et al. J Mol Biol, 2008 Sep 5. PMID 18598703
  5. Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly. Karanasios E, et al. J Mol Biol, 2007 Dec 7. PMID 17976650

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables methionine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables methionine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methionyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
methionine--tRNA ligase MSM1
NP_011687.1
  • Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    840824..842551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181300.1 → NP_011687.1  TPA: methionine--tRNA ligase MSM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUV5, P22438
    UniProtKB/TrEMBL
    A0A8H4C2Z6, A6ZUI3, B3LI59, B5VJB6, C7GQ78, C8Z967, N1P2F5
    Conserved Domains (1) summary
    TIGR00398
    Location:15 → 550
    metG; methionine--tRNA ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22438.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous