U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PDX1 Pdx1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853107, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
PDX1
Gene description
Pdx1p
Primary source
FungiDB:YGR193C
Locus tag
YGR193C
See related
SGD:S000003425; AllianceGenome:SGD:S000003425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables structural molecule activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Part of mitochondrial pyruvate dehydrogenase complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (884509..885741, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene histidine permease Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 Neighboring gene xylulokinase Neighboring gene exosome non-catalytic core subunit SKI6

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pyruvate dehydrogenase complex from baker's yeast. 1. Purification and some kinetic and regulatory properties. Kresze GB, et al. Eur J Biochem, 1981 Oct. PMID 7030740
  2. Cloning and nucleotide sequence of the gene for protein X from Saccharomyces cerevisiae. Behal RH, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2682658, Free PMC Article
  3. X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases. Neuwirth M, et al. FEBS Lett, 2009 Jul 7. PMID 19523954
  4. Pyruvate dehydrogenase complex from baker's yeast. 2. Molecular structure, dissociation, and implications for the origin of mitochondria. Kresze GB, et al. Eur J Biochem, 1981 Oct. PMID 7030741
  5. Expression, purification, and characterization of the dihydrolipoamide dehydrogenase-binding protein of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae. Maeng CY, et al. Biochemistry, 1994 Nov 22. PMID 7947791

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the yeast Pdx1 C-terminus contacts an adjacent subunit, and deletion of this segment decreases enzymatic activity 3.5-fold, suggesting a role in catalysis.
    Title: X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural molecule activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural molecule activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of pyruvate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pyruvate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of pyruvate dehydrogenase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Pdx1p
NP_011709.1
  • E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    884509..885741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181322.1 → NP_011709.1  TPA: Pdx1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011709.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUX5, E9P906, P16451
    UniProtKB/TrEMBL
    A0A8H4C2I2, A6ZUK3, C7GRM5, G2WES1, N1P9Y0
    Conserved Domains (1) summary
    COG0508
    Location:31 → 410
    AceF; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16451.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous